Generalised pustular psoriasis complicated by acute respiratory failure
, 3, 2
Abstract
We present a case of a female admitted to the Department of Dermatology, due to a generalised pustular eruption. The first symptoms appeared after a respiratory tract infection 4 months before the hospitalisation and were treated with systemic cyclosporine. Two weeks before hospital admission the treatment was discontinued. On admission, the patient was in a good general condition with laboratory tests revealing increased CRP (C Reactive Protein) and significant anaemia. The patient underwent multiple blood transfusions, subsequently, the course of the disease was complicated by respiratory failure requiring intubation and transfer to the intensive care unit. Increased serum inflammatory markers and procalcitonin levels along with negative blood and skin cultures were observed during the hospital stay. Based on the clinical picture, laboratory tests and the course of the disease a diagnosis of generalised pustular psoriasis was made. The patient was treated with symptomatic treatment, intravenous immunoglobulin infusions and oral acitretin with gradual resolution of the skin lesions.
Keywords: generalised pustular psoriasisacute respiratory failureacute generalised exanthematous pustulosis
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