Graham-Little Syndrome — a rare entity of both scarring and non-scarring alopecia concomitance

Abstract

Graham Little-Piccardi-Lassueur syndrome also called in a shorter form as Graham-Little syndrome, is a rare clinical entity characterized by the symptomatic triad including multifocal progressive cicatricial alopecia on the scalp, non-scarring hair loss of axillae and pubic areas and presence of keratosis pilaris-like eruption on the trunk and extremities. The etiology of the disease remains unknown with some hypotheses proposed. The condition is diagnosed based on clinical presentation, trichoscopical characteristic findings and histopathological analysis. The treatment of the syndrome is challenging. The therapeutic strategy includes topical or systemic corticosteroids, retinoids and PUVA therapy with different efficacy. We present the case of this rare syndrome and discuss it from the practical point of view in terms of diagnosis and treatment approach.