open access
The effect of Dermedic Linum Emolient care products on selected parameters of objective and subjective barriers epidermis in patients with various types of eczema
Affiliations- Dermoklinika Centrum Medyczne s.c., Kościuszki 93, 90-436 Łódź, Poland
open access
Abstract
Introduction: Functioning of the epidermal barrier depends on its proper construction — the content of the fatty acids, keratin as well as corneocytes and corneodesmosomes. Disruption of metabolic processes within the epidermis leads to skin inflammation, including eczema. Unfortunately, the number of studies assessing the effect of emollients on biophysical skin parameters are lacking.
Materials and methods: 30 adults with different types of eczema were enrolled into the study. Participants of the study used Dermedic Linum Emolient series for 4 weeks (28 days). Each participant used a whole range of preparations according to the pattern: intensively oiling preparation, scalp-protecting shampoo and lipid-protective cream every day, bath and shower oil 2 times a week.
Results: After 4 weeks of the study, significant reduction of epidermal water loss (TEWL) was observed on the forehead skin: 12.98 ± 3.74 to 7.86 ± 3.69 g/h/m2, torso: 7.79 ± 3.3 to 5.14 ± 1.65 g/h/m2 and lower legs: 8.80 ± 3.84 to 6.74 ± 20.95 g/h/m2. Sebum secretion increased significantly on the skin of the forearms (mean ± SD): 27.31 ± 10.72 to 52.65 ± 16.95 μg/cm, torso: 22.51 ± 6.46 to 44.89 ± 17.84 μg/cm2 and lower legs: 25.36 ± 9.17 to 38.15 ± 21.93 μg/cm2.
Conclusions: The study shows in an objective way that the regular use of Dermedic Linum emollients improves biophysical skin parameters, as well as reduces the severity of pruritus, redness and skin dryness in patients with different types of eczema.
Abstract
Introduction: Functioning of the epidermal barrier depends on its proper construction — the content of the fatty acids, keratin as well as corneocytes and corneodesmosomes. Disruption of metabolic processes within the epidermis leads to skin inflammation, including eczema. Unfortunately, the number of studies assessing the effect of emollients on biophysical skin parameters are lacking.
Materials and methods: 30 adults with different types of eczema were enrolled into the study. Participants of the study used Dermedic Linum Emolient series for 4 weeks (28 days). Each participant used a whole range of preparations according to the pattern: intensively oiling preparation, scalp-protecting shampoo and lipid-protective cream every day, bath and shower oil 2 times a week.
Results: After 4 weeks of the study, significant reduction of epidermal water loss (TEWL) was observed on the forehead skin: 12.98 ± 3.74 to 7.86 ± 3.69 g/h/m2, torso: 7.79 ± 3.3 to 5.14 ± 1.65 g/h/m2 and lower legs: 8.80 ± 3.84 to 6.74 ± 20.95 g/h/m2. Sebum secretion increased significantly on the skin of the forearms (mean ± SD): 27.31 ± 10.72 to 52.65 ± 16.95 μg/cm, torso: 22.51 ± 6.46 to 44.89 ± 17.84 μg/cm2 and lower legs: 25.36 ± 9.17 to 38.15 ± 21.93 μg/cm2.
Conclusions: The study shows in an objective way that the regular use of Dermedic Linum emollients improves biophysical skin parameters, as well as reduces the severity of pruritus, redness and skin dryness in patients with different types of eczema.
Keywords
emollients, eczema, TEWL
About this articleTitle
The effect of Dermedic Linum Emolient care products on selected parameters of objective and subjective barriers epidermis in patients with various types of eczema
Journal
Issue
Article type
Research paper
Pages
96-99
Published online
2018-09-03
Page views
562
Article views/downloads
1219
Bibliographic record
Forum Dermatologicum 2018;4(3):96-99.
Keywords
emollients
eczema
TEWL
Authors
Aleksandra Lesiak
Igor Aleksander Bednarski
Anna Maćkowska
Joanna Narbutt
References (7)- Voegeli D. The vital role of emollients in the treatment of eczema. Br J Nurs. 2011; 20(2): 74–80.
- Brown S, Reynolds NJ. Atopic and non-atopic eczema. BMJ. 2006; 332(7541): 584–588.
- Stemmler S, Nothnagel M, Parwez Q, et al. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. Int J Immunogenet. 2009; 36(4): 217–222.
- Di Nardo A, Wertz P, Giannetti A, et al. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. 1998; 78(1): 27–30.
- Schmitt J, Apfelbacher CJ, Flohr C. Eczema. BMJ Clin Evid. 2011; 2011: pii: 1716.
- Clark C. How to choose a suitable emollient. Pharmaceutical Journal. 2004; 273: 351–352.
- Sidbury R, Davis DM, Cohen DE, et al. American Academy of Dermatology. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol. 2014; 71(2): 327–349.
