Vol 3, No 2 (2017)
Review paper
Published online: 2017-08-21
Page views
2306
Article views/downloads
106642
Topical antibiotics in the treatment of acne
Forum Dermatologicum 2017;3(2):49-52.
Abstract
Acne vulgaris is one of the most common reason of dermatological consultation. Pathogenesis of acne is multifactorial, including hormonal disturbances, genetic factors, changes in sebum composition, and colonization of hair follicles with Propionibacterium acnes. About 80% of acne cases have a mild course, which should be treated with topical therapy and proper skin care. Topical anti-acne drugs include antibiotics, retinoids, benzoyl peroxide, and azelaic acid. Antibiotics have antimicrobial and anti-inflammatory properties. They inhibit chemotaxis of neutrophils, cytokine synthesis and macrophage functioning as well as they decrease the number of P. acnes in pilosebaceus units. In contrast to other topical treatment options, topical antibiotics do not cause skin irritation. They can also be safely used in pregnant women as well in children and adolescents.
Keywords: erythromycinclindamycintreatmentPrionibacterium acnes
References
- Toyoda M, Morohashi M. Pathogenesis of acne. Medical Electron Microscopy. 2001; 34(1): 29–40.
- Nast A, Dréno B, Bettoli V, et al. European evidence-based (S3) guideline for the treatment of acne - update 2016 - short version. J Eur Acad Dermatol Venereol. 2016; 30(8): 1261–1268.
- Seaton E. Recommended treatment options in acne management. Prescriber. 2006; 17(17): 44–55.
- Placek W , Romańska-Gocka K , Grzanka A Leczenie miejscowe trądziku Przegl Dermatol. 2011; 98: 442–448.
- Zaenglein AL, Thiboutot DM. Expert committee recommendations for acne management. Pediatrics. 2006; 118(3): 1188–1199.
- Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016; 74(5): 945–73.e33.
- Simonart T, Dramaix M. Treatment of acne with topical antibiotics: lessons from clinical studies. Br J Dermatol. 2005; 153(2): 395–403.
- Dreno B. Topical Antibacterial Therapy for Acne Vulgaris. Drugs. 2004; 64(21): 2389–2397.
- Gelmetti C. Local antibiotics in dermatology. Dermatol Ther. 2008; 21(3): 187–195.
- Plewig G, Holland KT, Nenoff P. Clinical and bacteriological evaluation of nadifloxacin 1% cream in patients with acne vulgaris: a double-blind, phase III comparison study versus erythromycin 2% cream. Eur J Dermatol. 2006; 16(1): 48–55.
- Zouboulis CC, Derumeaux L, Decroix J, et al. A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris. Br J Dermatol. 2000; 143(3): 498–505.
- Cunliffe WJ, Holland KT, Bojar R, et al. A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris. Clin Ther. 2002; 24(7): 1117–1133.
- Szepietowski J, Kapińska-Mrowiecka M, Kaszuba A, et al. Trądzik zwyczajny: patogeneza i leczenie. Konsensus Polskiego Towarzystwa ogicznego. Przegl Dermatol. 2012; 99: 649–673.
- Bojarska-Dahlig H, Slawinski W, Roślik-Kamińska D, et al. L-aspartate of erythromycin A cyclic 11,12-carbonate, a new semisynthetic erythromycin derivative. J Antibiot (Tokyo). 1976; 29(9): 907–914.
- Jeljaszewicz J. Davercin cykliczny węglan erytromycyny — nowy oryginalny polski antybiotyk. Biuro Wydawnicze „Chemia, Warszawa 1981.
- Gollnick H. Current concepts of the pathogenesis of acne: implications for drug treatment. Drugs. 2003; 63(15): 1579–1596.
- Thiboutot D, Gollnick H, Bettoli V, et al. Global Alliance to Improve Outcomes in Acne. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. 2009; 60(5 Suppl): S1–50.
- Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol. 2003; 49(3 Suppl): S200–S210.
- Kaszuba A, Pastuszka M, Kaszuba A. Trądzik pospolity: leczenie miejscowe preparatami prostymi w terapii naprzemiennej. Dermatol Prakt. 2010; 4: 3–12.
- Bojar RA, Eady EA, Jones CE, et al. Inhibition of erythromycin-resistant propionibacteria on the skin of acne patients by topical erythromycin with and without zinc. Br J Dermatol. 1994; 130(3): 329–336.
- Burkhart CG, Burkhart CN, Isham N. Synergistic antimicrobial activity by combining an allylamine with benzoyl peroxide with expanded coverage against yeast and bacterial species. Br J Dermatol. 2006; 154(2): 341–344.
- McKeage K, Keating GM. Clindamycin/benzoyl peroxide gel (BenzaClin): a review of its use in the management of acne. Am J Clin Dermatol. 2008; 9(3): 193–204.
- Thiboutot DM, Weiss J, Bucko A, et al. Adapalene-BPO Study Group. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. J Am Acad Dermatol. 2007; 57(5): 791–799.
- Leyden JJ, Preston N, Osborn C, et al. In-vivo Effectiveness of Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel on Antibiotic-sensitive and Resistant Propionibacterium acnes. J Clin Aesthet Dermatol. 2011; 4(5): 22–26.
- Pariser DM, Westmoreland P, Morris A, et al. Long-term safety and efficacy of a unique fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide 2.5% for the treatment of acne vulgaris. J Drugs Dermatol. 2007; 6(9): 899–905.
