Vol 3, No 2 (2017)
Review paper
Published online: 2017-08-21
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Topical antibiotics in the treatment of acne
Forum Dermatologicum 2017;3(2):49-52.
Abstract
Acne vulgaris is one of the most common reason of dermatological consultation. Pathogenesis of acne is multifactorial, including hormonal disturbances, genetic factors, changes in sebum composition, and colonization of hair follicles with Propionibacterium acnes. About 80% of acne cases have a mild course, which should be treated with topical therapy and proper skin care. Topical anti-acne drugs include antibiotics, retinoids, benzoyl peroxide, and azelaic acid. Antibiotics have antimicrobial and anti-inflammatory properties. They inhibit chemotaxis of neutrophils, cytokine synthesis and macrophage functioning as well as they decrease the number of P. acnes in pilosebaceus units. In contrast to other topical treatment options, topical antibiotics do not cause skin irritation. They can also be safely used in pregnant women as well in children and adolescents.
Keywords: erythromycinclindamycintreatmentPrionibacterium acnes
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