open access

Vol 2, No 2 (2016)
Case report
Published online: 2016-09-15
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Porphyria cutanea tarda — a case report of severe course of disease in a female with alcohol addiction

Dorota Maria Mehrholz, Paulina Flis, Andriy Petranyuk, Małgorzata Sokołowska-Wojdyło, Roman Nowicki, Wioletta Barańska-Rybak
Forum Dermatologicum 2016;2(2):90-94.

open access

Vol 2, No 2 (2016)
CASE STUDY
Published online: 2016-09-15

Abstract

Porphyria cutanea tarda (PCT) belongs to the group of diseases with an increased incidence in the population of alcohol addicted people. Ethanol consumption has an influence on porphiryn metabolism which leads to disturbance in regulation of heme synthesis enzymes as well as direct damage of hepatocytes. Porphyria is a disease which involves disturbance of hepatic heme synthesis enzymes. In the course of the PCT, porphyrines are accumulated in the skin and excreted with urine. The skin lesions occur during porphyrin disintegration caused by UV light. The clinical presentation of PCT is non-inflammatory blisters, occasionally accompanied by hemorrhage and eschar. Chronic skin damage may result in scarring and changes in pigmentation at the sites of blisters and milia. Other clinical symptoms include: arthritic pain of upper and lower extremities, dizziness, tinnitus, abdominal pain and sudden death. We present extremely severe case of PCT in female, which was induced by sun exposure, hormone replacement therapy and alcohol intake.

Abstract

Porphyria cutanea tarda (PCT) belongs to the group of diseases with an increased incidence in the population of alcohol addicted people. Ethanol consumption has an influence on porphiryn metabolism which leads to disturbance in regulation of heme synthesis enzymes as well as direct damage of hepatocytes. Porphyria is a disease which involves disturbance of hepatic heme synthesis enzymes. In the course of the PCT, porphyrines are accumulated in the skin and excreted with urine. The skin lesions occur during porphyrin disintegration caused by UV light. The clinical presentation of PCT is non-inflammatory blisters, occasionally accompanied by hemorrhage and eschar. Chronic skin damage may result in scarring and changes in pigmentation at the sites of blisters and milia. Other clinical symptoms include: arthritic pain of upper and lower extremities, dizziness, tinnitus, abdominal pain and sudden death. We present extremely severe case of PCT in female, which was induced by sun exposure, hormone replacement therapy and alcohol intake.

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Keywords

alcohol, PCT, porphyria cutanea tarda, hormonal replacement therapy

About this article
Title

Porphyria cutanea tarda — a case report of severe course of disease in a female with alcohol addiction

Journal

Forum Dermatologicum

Issue

Vol 2, No 2 (2016)

Article type

Case report

Pages

90-94

Published online

2016-09-15

Page views

9364

Article views/downloads

4252

Bibliographic record

Forum Dermatologicum 2016;2(2):90-94.

Keywords

alcohol
PCT
porphyria cutanea tarda
hormonal replacement therapy

Authors

Dorota Maria Mehrholz
Paulina Flis
Andriy Petranyuk
Małgorzata Sokołowska-Wojdyło
Roman Nowicki
Wioletta Barańska-Rybak

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