open access
Lyell’s syndrome
open access
Abstract
Lyell’s syndrome is a life-threatening skin condition that is caused by a reaction to drugs. Clinical presentation includes erythematous lesions with blisters on the skin and mucosal erosions. The clinical picture resembles an extensive skin burn. The mortality rate is around 30% and depends on the clinical status of the patient, the time of initiation of treatment and aggressiveness of therapy. As the etiology of the disease is not fully understood the treatment is mostly symptomatic. In the systemic treatment steroids, cyclosporine, immunoglobulins, infliximab and plasmapheresis can be considered.
Abstract
Lyell’s syndrome is a life-threatening skin condition that is caused by a reaction to drugs. Clinical presentation includes erythematous lesions with blisters on the skin and mucosal erosions. The clinical picture resembles an extensive skin burn. The mortality rate is around 30% and depends on the clinical status of the patient, the time of initiation of treatment and aggressiveness of therapy. As the etiology of the disease is not fully understood the treatment is mostly symptomatic. In the systemic treatment steroids, cyclosporine, immunoglobulins, infliximab and plasmapheresis can be considered.
Keywords
toxic epidermal necrolysis, Stevens-Johnson syndrome, drug-induced eruptions, sulfasalazine
About this articleTitle
Lyell’s syndrome
Journal
Issue
Article type
Case report
Pages
33-37
Published online
2016-05-09
Page views
1122
Article views/downloads
35698
Bibliographic record
Forum Dermatologicum 2016;2(1):33-37.
Keywords
toxic epidermal necrolysis
Stevens-Johnson syndrome
drug-induced eruptions
sulfasalazine
Authors
Monika Heisig
Adam Reich
