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Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model
, 2, 3, 4, 5, 3, 3, 3
Affiliations- Department of General Surgery, Batman Regional Public Hospital, Batman, Türkiye
- Gaziantep Medical Park Hospital, Gaziantep, Türkiye
- Department of General Surgery, Faculty of Medicine, University of Dicle, Diyarbakır, Türkiye
- Department of Anatomy, Faculty of Medicine, University of Dicle, Diyarbakır, Türkiye
- Department of Pathology, Diyarbakır Educating and Research Hospital, Diyarbakır, Türkiye
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Abstract
Background: The aim of the study was to compare the effects of rosmarinic acid and dexpanthenol in a rat experimental wound model.
Materials and methods: Twenty-four Wistar albino rats weighing 200–250 g were randomly divided into three groups. After 2-cm full-thickness skin defects were created, the wounds were washed with sterile 0.9% NaCl solution. After washing, the control group was left untreated, the second group received 5% dexpanthenol cream, and the third group received 10% rosmarinic acid cream. Before excision, the skin was evaluated macroscopically by measuring the reduction in wound size; after excision, histological examination (epithelisation, inflammation, fibrosis, granulation) was performed.
Results: Macroscopic comparison of the wound sizes showed that group 3 showed a statistically significant difference in wound size reduction compared to the other two groups. Histopathological examination showed that there was no statistically significant difference between the groups. We found that the rosmarinic acid group had greater wound size reduction than the other two groups. However, epithelialisation was detected in fewer cases.
Conclusions: We believe that rosmarinic acid can be used as a topical cream for wound healing, as it leads to significant reduction in wound size, resulting in fewer scars.
Abstract
Background: The aim of the study was to compare the effects of rosmarinic acid and dexpanthenol in a rat experimental wound model.
Materials and methods: Twenty-four Wistar albino rats weighing 200–250 g were randomly divided into three groups. After 2-cm full-thickness skin defects were created, the wounds were washed with sterile 0.9% NaCl solution. After washing, the control group was left untreated, the second group received 5% dexpanthenol cream, and the third group received 10% rosmarinic acid cream. Before excision, the skin was evaluated macroscopically by measuring the reduction in wound size; after excision, histological examination (epithelisation, inflammation, fibrosis, granulation) was performed.
Results: Macroscopic comparison of the wound sizes showed that group 3 showed a statistically significant difference in wound size reduction compared to the other two groups. Histopathological examination showed that there was no statistically significant difference between the groups. We found that the rosmarinic acid group had greater wound size reduction than the other two groups. However, epithelialisation was detected in fewer cases.
Conclusions: We believe that rosmarinic acid can be used as a topical cream for wound healing, as it leads to significant reduction in wound size, resulting in fewer scars.
Keywords
wound healing, rosmarinic acid, dexpanthenol, rat
About this articleTitle
Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model
Journal
Issue
Article type
Original article
Pages
618-624
Published online
2020-08-22
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7410
Article views/downloads
1511
DOI
Pubmed
Bibliographic record
Folia Morphol 2021;80(3):618-624.
Keywords
wound healing
rosmarinic acid
dexpanthenol
rat
Authors
M. C. Küba
A. Türkoğlu
A. Oğuz
M. C. Tuncer
Ş. Kaya
Ö. Başol
H. Bilge
F. Tatlı
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