open access
Is amygdala size correlated with stress?
, 2, 1, 3, 4
Affiliations- Department of Anatomy, İnönü University, Malatya, Türkiye
- Department of Radiology, İnönü University, Malatya, Türkiye
- Department of Physiology, Adıyaman University, Adıyaman, Türkiye
- Department of Physiology, İnönü University, Malatya, Türkiye
open access
Abstract
Background: One of the important mechanisms that regulate the stress response of the body is hypothalamic pituitary adrenal axis. One of the structures activating this axis is amygdala. We have seen people around who react calmer and cooler to very stressful situations. Are people with smaller amygdala really calmer? Or, can we say that the bigger the amygdala, which is the trigger of the body’s response to stress, the more a person panics? Aim of the study is to compare the saliva cortisol levels and amygdala volume.
Materials and methods: Study conducted with 63 male students. Magnetic resonance images of students were taken before their final exam to calculate amygdala volumes. Saliva samples of all students were taken two times to detect cortisol levels in saliva. First one was 20 days before the final exam and second one was on the exam day. We assumed that the students were stressful on exam day.
Results and Conclusions: No statistically significant correlation was found between saliva cortisol levels and amygdala volume in the study.
Abstract
Background: One of the important mechanisms that regulate the stress response of the body is hypothalamic pituitary adrenal axis. One of the structures activating this axis is amygdala. We have seen people around who react calmer and cooler to very stressful situations. Are people with smaller amygdala really calmer? Or, can we say that the bigger the amygdala, which is the trigger of the body’s response to stress, the more a person panics? Aim of the study is to compare the saliva cortisol levels and amygdala volume.
Materials and methods: Study conducted with 63 male students. Magnetic resonance images of students were taken before their final exam to calculate amygdala volumes. Saliva samples of all students were taken two times to detect cortisol levels in saliva. First one was 20 days before the final exam and second one was on the exam day. We assumed that the students were stressful on exam day.
Results and Conclusions: No statistically significant correlation was found between saliva cortisol levels and amygdala volume in the study.
Keywords
amygdala volume, saliva cortisol, stress, magnetic resonance images
About this articleTitle
Is amygdala size correlated with stress?
Journal
Issue
Article type
Original article
Pages
514-519
Published online
2020-08-14
Page views
7012
Article views/downloads
1391
DOI
Pubmed
Bibliographic record
Folia Morphol 2021;80(3):514-519.
Keywords
amygdala volume
saliva cortisol
stress
magnetic resonance images
Authors
M. Canbolat
M. F. Erbay
D. Şenol
C. Uçar
S. Yıldız
References (35)- Baur V, Hänggi J, Jäncke L. Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety. BMC Neurosci. 2012; 13: 4.
- Beheshtifar M, Hoseinifar H, Moghadam M. Effect procrastination on work-related stress. Eur J Econ Finance Admin Sci. 2011; 38: 59–64.
- Duboc V, Dufourcq P, Blader P, et al. Asymmetry of the brain: development and implications. Annu Rev Genet. 2015; 49: 647–672.
- Fernández-Blázquez MA, Ávila-Villanueva M, López-Pina JA, et al. Psychometric properties of a new short version of the State-Trait Anxiety Inventory (STAI) for the assessment of anxiety in the elderly. Neurologia. 2015; 30(6): 352–358.
- Gatti R, Antonelli G, Prearo M, et al. Cortisol assays and diagnostic laboratory procedures in human biological fluids. Clin Biochem. 2009; 42(12): 1205–1217.
- Gerritsen L, Rijpkema M, van Oostrom I, et al. Amygdala to hippocampal volume ratio is associated with negative memory bias in healthy subjects. Psychol Med. 2012; 42(2): 335–343.
- Gotink RA, Vernooij MW, Ikram MA, et al. Meditation and yoga practice are associated with smaller right amygdala volume: the Rotterdam study. Brain Imaging Behav. 2018; 12(6): 1631–1639.
- Granger DA, Kivlighan KT, el-Sheikh M, et al. Salivary alpha-amylase in biobehavioral research: recent developments and applications. Ann N Y Acad Sci. 2007; 1098: 122–144.
- Holmes AJ, Lee PH, Hollinshead MO, et al. Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk. J Neurosci. 2012; 32(50): 18087–18100.
- Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015; 22(9): 411–416.
- Koob GF. The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res. 2010; 1314: 3–14.
- Kronenberg G, Tebartz van Elst L, Regen F, et al. Reduced amygdala volume in newly admitted psychiatric in-patients with unipolar major depression. J Psychiatr Res. 2009; 43(13): 1112–1117.
- Kudielka B, Hellhammer DH, Wüst S. Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology. 2009; 34(1): 2–18.
- Leal PC, Goes TC, da Silva LC, et al. Trait vs. state anxiety in different threatening situations. Trends Psychiatry Psychother. 2017; 39(3): 147–157.
- Lederbogen F, Kirsch P, Haddad L, et al. City living and urban upbringing affect neural social stress processing in humans. Nature. 2011; 474(7352): 498–501.
- LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol. 2003; 23(4-5): 727–738.
- Lee DoY, Kim E, Choi MHo. Technical and clinical aspects of cortisol as a biochemical marker of chronic stress. BMB Rep. 2015; 48(4): 209–216.
- Lee SC, Amir A, Haufler D, et al. Differential recruitment of competing valence-related amygdala networks during anxiety. Neuron. 2017; 96(1): 81–88.e5.
- Malykhin N, Travis S, Sereshki A, et al. 132. Effects of cortisol on hippocampal subfields and centromedial amygdala volumes in healthy subjects and patients with major depressive disorder. Biol Psychiatry. 2018; 83(9): S54.
- Marin MF, Lord C, Andrews J, et al. Chronic stress, cognitive functioning and mental health. Neurobiol Learn Mem. 2011; 96(4): 583–595.
- Morris JS, Ohman A, Dolan RJ. A subcortical pathway to the right amygdala mediating "unseen" fear. Proc Natl Acad Sci U S A. 1999; 96(4): 1680–1685.
- Özel Y, Karabulut AB. Daily living and stress management. Turkish J Health Sci Res. 2018; 1(1): 48–56.
- Pedraza O, Bowers D, Gilmore R. Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. J Int Neuropsychol Soc. 2004; 10(5): 664–678.
- Ping LT, Subramaniam K, Krishnaswamy S. Test anxiety: state, trait and relationship with exam satisfaction. Malays J Med Sci. 2008; 15(2): 18–23.
- Schuhmacher A, Mössner R, Jessen F, et al. Association of amygdala volumes with cortisol secretion in unipolar depressed patients. Psychiatry Res. 2012; 202(2): 96–103.
- Sharma D. Physiology of stress and its management. J Med Study Res. 2018; 1(1): 1–5.
- Sharma M, Rush SE. Mindfulness-based stress reduction as a stress management intervention for healthy individuals: a systematic review. J Evid Based Complementary Altern Med. 2014; 19(4): 271–286.
- Spangler G. Psychological and physiological responses during an exam and their relation to personality characteristics. Psychoneuroendocrinology. 1997; 22(6): 423–441.
- Spiga F, Walker JJ, Terry JR, et al. HPA axis-rhythms. Compr Physiol. 2014; 4(3): 1273–1298.
- Tottenham N, Hare TA, Quinn BT, et al. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev Sci. 2010; 13(1): 46–61.
- Tottenham N, Sheridan MA. A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing. Front Hum Neurosci. 2009; 3: 68–77.
- Tufan AE, Yaluğ İ. Love phenomenon and neurobiology of love relations. Curr App Psychiatry. 2010; 2(4): 443–456.
- van der Plas EAA, Boes AD, Wemmie JA, et al. Amygdala volume correlates positively with fearfulness in normal healthy girls. Soc Cogn Affect Neurosci. 2010; 5(4): 424–431.
- Wang Q, Verweij EWE, Krugers HJ, et al. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Struct Funct. 2014; 219(5): 1615–1626.
- Yıldız M, Güç K, Erdem S. Examine attitudes to cope with stress in terms of human values: a study on public employees. Sci J Turkish Military Academy. 2015; 25(1): 41–61.
