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Arthrogenic human synovial cysts: immunohistochemical profile of interleukin-1beta, interleukin-6, tumour necrosis factor-alpha
Affiliations- Department of Sensory Organs, “Sapienza” University of Rome
- Department of Human Neurosciences, “Sapienza” University of Rome
- Orthopaedic Unit and Kirk Kilgour Sports Injury Centre, Sant’Andrea Hospital, University of Rome “Sapienza”, Rome
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Abstract
Background: Synovial cysts are currently classified as degenerative lesions affecting
the joint capsule or adjacent structures.
Materials and methods: In our study we describe the results obtained in an immunohistochemical
study comprising 18 patients with synovial cysts, performed
to evaluate the pathophysiological role of some inflammatory cytokines such as:
interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α).
Results: Results showed an over-expression of TNF-α, IL-1β and IL-6 which appears
to be involved in the onset and progression of the disease. At the present
time it is not possible to affirm that these molecules play a direct role also due
to the absence of further and more specific investigations. The authors therefore
hypothesize that inhibition of inflammation may have a significant role in the
pathogenesis and regression of synovial cysts.
Conclusions: Hence, these inflammatory cytokines may be considered potential
therapeutic targets. The development of synthetic inhibitors of these inflammatory
factors could lead to a reduction in the intensity of inflammation, thus inhibiting
the onset and development of the disease.
Abstract
Background: Synovial cysts are currently classified as degenerative lesions affecting
the joint capsule or adjacent structures.
Materials and methods: In our study we describe the results obtained in an immunohistochemical
study comprising 18 patients with synovial cysts, performed
to evaluate the pathophysiological role of some inflammatory cytokines such as:
interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α).
Results: Results showed an over-expression of TNF-α, IL-1β and IL-6 which appears
to be involved in the onset and progression of the disease. At the present
time it is not possible to affirm that these molecules play a direct role also due
to the absence of further and more specific investigations. The authors therefore
hypothesize that inhibition of inflammation may have a significant role in the
pathogenesis and regression of synovial cysts.
Conclusions: Hence, these inflammatory cytokines may be considered potential
therapeutic targets. The development of synthetic inhibitors of these inflammatory
factors could lead to a reduction in the intensity of inflammation, thus inhibiting
the onset and development of the disease.
Keywords
interleukins 1beta and 6, immunohistochemistry, synovial cysts, tumour necrosis factor-alpha
About this articleTitle
Arthrogenic human synovial cysts: immunohistochemical profile of interleukin-1beta, interleukin-6, tumour necrosis factor-alpha
Journal
Issue
Article type
Original article
Pages
133-139
Published online
2020-02-20
Page views
1061
Article views/downloads
1285
DOI
Pubmed
Bibliographic record
Folia Morphol 2021;80(1):133-139.
Keywords
interleukins 1beta and 6
immunohistochemistry
synovial cysts
tumour necrosis factor-alpha
Authors
S. Taurone
M. T. Santarelli
C. De Ponte
L. Bardella
M. Ralli
C. Morselli
A. Nicolai
A. Greco
A. Ferretti
M. Artico
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