Arthrogenic human synovial cysts: immunohistochemical profile of interleukin-1beta, interleukin-6, tumour necrosis factor-alpha
Abstract
Background: Synovial cysts are currently classified as degenerative lesions affecting
the joint capsule or adjacent structures.
Materials and methods: In our study we describe the results obtained in an immunohistochemical
study comprising 18 patients with synovial cysts, performed
to evaluate the pathophysiological role of some inflammatory cytokines such as:
interleukin (IL)-1β, IL-6 and tumour necrosis factor-alpha (TNF-α).
Results: Results showed an over-expression of TNF-α, IL-1β and IL-6 which appears
to be involved in the onset and progression of the disease. At the present
time it is not possible to affirm that these molecules play a direct role also due
to the absence of further and more specific investigations. The authors therefore
hypothesize that inhibition of inflammation may have a significant role in the
pathogenesis and regression of synovial cysts.
Conclusions: Hence, these inflammatory cytokines may be considered potential
therapeutic targets. The development of synthetic inhibitors of these inflammatory
factors could lead to a reduction in the intensity of inflammation, thus inhibiting
the onset and development of the disease.
Keywords: interleukins 1beta and 6immunohistochemistrysynovial cyststumour necrosis factor-alpha
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