open access

Vol 80, No 1 (2021)
Original article
Submitted: 2019-12-13
Accepted: 2020-01-23
Published online: 2020-02-13
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Effect of vitamin B17 on experimentally induced colon cancer in adult male albino rat

W. Badr El-Kholy1, S. A. Abdel-Rahman1, F. E.-N. Abd El-Hady El-Safti1, N. Mohey Issa1
·
Pubmed: 32073131
·
Folia Morphol 2021;80(1):158-169.
Affiliations
  1. Human Anatomy and Embryology, Faculty of Medicine, Menoufia University

open access

Vol 80, No 1 (2021)
ORIGINAL ARTICLES
Submitted: 2019-12-13
Accepted: 2020-01-23
Published online: 2020-02-13

Abstract

Background: Colon cancer is considered to be the third most common cancer worldwide. At diagnosis of colon cancer, 3.7–11% developed bone metastasis. Diet based strategies are important for prevention and treatment of colon cancer. This study investigated the effect of vitamin B17 on a DMH induced rat model of colon cancer.

Materials and methods: Eighty young adult male albino rats were divided into five groups: group I (control group), group II (vitamin B17), group III (colon cancer), group IV (protected) and group V (treated). Distal colon sections were prepared for light and scanning electron microscopic examination. Lumbar vertebrae specimens were prepared for light microscopic study. Morphometric and statistical analysis were done.

Results: In comparison with the control, both colon cancer and treated groups showed invasion of the colonic tissue by pleomorphic branching colonic glands of variable shapes and sizes lined with dysplastic elongated hyperchromatic nuclei with frequent mitotic figures or stratified multi-layered crowded nuclei with an extremely significant (p < 0.0001) reduction of goblet cell number when compared to the control together with major pathological bone changes were observed in colon cancer and the treated groups.

Conclusions: While the protected group showed impressive improvement of all previously mentioned diameters.

Abstract

Background: Colon cancer is considered to be the third most common cancer worldwide. At diagnosis of colon cancer, 3.7–11% developed bone metastasis. Diet based strategies are important for prevention and treatment of colon cancer. This study investigated the effect of vitamin B17 on a DMH induced rat model of colon cancer.

Materials and methods: Eighty young adult male albino rats were divided into five groups: group I (control group), group II (vitamin B17), group III (colon cancer), group IV (protected) and group V (treated). Distal colon sections were prepared for light and scanning electron microscopic examination. Lumbar vertebrae specimens were prepared for light microscopic study. Morphometric and statistical analysis were done.

Results: In comparison with the control, both colon cancer and treated groups showed invasion of the colonic tissue by pleomorphic branching colonic glands of variable shapes and sizes lined with dysplastic elongated hyperchromatic nuclei with frequent mitotic figures or stratified multi-layered crowded nuclei with an extremely significant (p < 0.0001) reduction of goblet cell number when compared to the control together with major pathological bone changes were observed in colon cancer and the treated groups.

Conclusions: While the protected group showed impressive improvement of all previously mentioned diameters.

Get Citation

Keywords

colon cancer rat, vitamin B17

About this article
Title

Effect of vitamin B17 on experimentally induced colon cancer in adult male albino rat

Journal

Folia Morphologica

Issue

Vol 80, No 1 (2021)

Article type

Original article

Pages

158-169

Published online

2020-02-13

Page views

2770

Article views/downloads

10921

DOI

10.5603/FM.a2020.0021

Pubmed

32073131

Bibliographic record

Folia Morphol 2021;80(1):158-169.

Keywords

colon cancer rat
vitamin B17

Authors

W. Badr El-Kholy
S. A. Abdel-Rahman
F. E.-N. Abd El-Hady El-Safti
N. Mohey Issa

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