open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2019-06-27
Submitted: 2019-02-21
Accepted: 2019-04-01
Get Citation

Adverse effects of energy drink on rat pancreas and the therapeutic role of each of bone marrow mesenchymal stem cells and nigella sativa oil

Heshmat Haroun, Enas Mohamed, Abd El Rahman El Shahat, Heba Labib, Mariam Atef
DOI: 10.5603/FM.a2019.0069
·
Pubmed: 31257565

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2019-06-27
Submitted: 2019-02-21
Accepted: 2019-04-01

Abstract

Background and objectives: Energy drinks have been observed to threaten public health leading to many medical problems. Bone marrow-derived mesenchymal stem cells (BMSCs) have broad prospects in tissue regeneration. Nigella Sativa (NS) possess great therapeutic properties for the treatment of a wide range of diseases.

Material and Methods: Forty adult male albino rats were divided into: control group and treated group. The treated group was further subdivided into: energy drink subgroup 2a, BMSCs-injected subgroup 2b, NS-injected subgroup 2c. Histological, immunohistochemical and biochemical assessment was performed.

Results: Administration of energy drink revealed that it adversely affected the pancreatic cytoarchitecture. BMSCs and NS have been similarly observed to significantly ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.

Conclusions: The extent of pancreatic regeneration, exerted by each of BMSCs and NSO, is nearly similar but the effect of BMSCs is more superior, however, nigella sativa could be privileged to BMSCs as a line of treatment being easily accessible and of lower cost.

Abstract

Background and objectives: Energy drinks have been observed to threaten public health leading to many medical problems. Bone marrow-derived mesenchymal stem cells (BMSCs) have broad prospects in tissue regeneration. Nigella Sativa (NS) possess great therapeutic properties for the treatment of a wide range of diseases.

Material and Methods: Forty adult male albino rats were divided into: control group and treated group. The treated group was further subdivided into: energy drink subgroup 2a, BMSCs-injected subgroup 2b, NS-injected subgroup 2c. Histological, immunohistochemical and biochemical assessment was performed.

Results: Administration of energy drink revealed that it adversely affected the pancreatic cytoarchitecture. BMSCs and NS have been similarly observed to significantly ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.

Conclusions: The extent of pancreatic regeneration, exerted by each of BMSCs and NSO, is nearly similar but the effect of BMSCs is more superior, however, nigella sativa could be privileged to BMSCs as a line of treatment being easily accessible and of lower cost.

Get Citation

Keywords

energy drink, pancreas, bone marrow derived mesenchymal stem cells, nigella sativa

About this article
Title

Adverse effects of energy drink on rat pancreas and the therapeutic role of each of bone marrow mesenchymal stem cells and nigella sativa oil

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2019-06-27

DOI

10.5603/FM.a2019.0069

Pubmed

31257565

Keywords

energy drink
pancreas
bone marrow derived mesenchymal stem cells
nigella sativa

Authors

Heshmat Haroun
Enas Mohamed
Abd El Rahman El Shahat
Heba Labib
Mariam Atef

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By  "Via Medica sp. z o.o." sp.k., Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl