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Can constant light exposure affect the thyroid gland in prepubertal male albino rats? Histological and ultrastructural study
Affiliations- Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt
open access
Abstract
Background: Through scientific literature, there is evidence that light affects thyroid function in human, mice and rabbits. Constant light and sleep deprivation is also used as a form of human torture, as it has impact on cognitive performances. The present work was conducted to study the effect of constant light for short and long periods on the thyroid gland in the prepubertal male albino rats.
Materials and methods: A total of 30 prepubertal male albino rats were used. The rats separated into three groups: group I (control); group II were those rats put under steady encompassing light (24 h/day, light intensity of 600 lux) for 4 weeks; and group III were the rats maintained in constant light for 3 months. The rat thyroid gland was subjected to histological and ultrastructural examination.
Results: The rats exposed to light for long durations showed disturbed architecture; the follicles exhibited back to back arrangement (signs of hypertrophy with hyperplasia), lined by multiple layers of follicular cells or were lined by vacuolated cells. Few thyroid follicles exhibited cystic hyperplasia. Congested blood capillaries were demonstrated between the follicles.
Conclusions: It can be concluded that the short-term exposure to constant light for 1 month had no apparent effect on thyroid gland tissues while longer exposure to light for 3 months had detrimental effects on the thyroid gland structure of male albino rats.
Abstract
Background: Through scientific literature, there is evidence that light affects thyroid function in human, mice and rabbits. Constant light and sleep deprivation is also used as a form of human torture, as it has impact on cognitive performances. The present work was conducted to study the effect of constant light for short and long periods on the thyroid gland in the prepubertal male albino rats.
Materials and methods: A total of 30 prepubertal male albino rats were used. The rats separated into three groups: group I (control); group II were those rats put under steady encompassing light (24 h/day, light intensity of 600 lux) for 4 weeks; and group III were the rats maintained in constant light for 3 months. The rat thyroid gland was subjected to histological and ultrastructural examination.
Results: The rats exposed to light for long durations showed disturbed architecture; the follicles exhibited back to back arrangement (signs of hypertrophy with hyperplasia), lined by multiple layers of follicular cells or were lined by vacuolated cells. Few thyroid follicles exhibited cystic hyperplasia. Congested blood capillaries were demonstrated between the follicles.
Conclusions: It can be concluded that the short-term exposure to constant light for 1 month had no apparent effect on thyroid gland tissues while longer exposure to light for 3 months had detrimental effects on the thyroid gland structure of male albino rats.
Keywords
constant light; thyroid gland histological; prepubertal rats; thyroid gland ultrastructural
About this articleTitle
Can constant light exposure affect the thyroid gland in prepubertal male albino rats? Histological and ultrastructural study
Journal
Issue
Article type
Original article
Pages
297-306
Published online
2018-08-09
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2390
Article views/downloads
1187
DOI
Pubmed
Bibliographic record
Folia Morphol 2019;78(2):297-306.
Keywords
constant light
thyroid gland histological
prepubertal rats
thyroid gland ultrastructural
Authors
F.A. Abdel Gawad
E.A.A. El-Shaarawy
S.F. Arsanyos
T.I. Abd El-Galil
G.N. Awes
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