open access

Vol 77, No 3 (2018)
Original article
Submitted: 2017-07-18
Accepted: 2017-11-10
Published online: 2017-11-27
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Endothelial expression of c-kit and CD68 in dental follicles of human impacted third molars

M. C. Rusu1, A. Rașcu1, M. D. Stoenescu1
·
Pubmed: 29235086
·
Folia Morphol 2018;77(3):485-488.
Affiliations
  1. Division of Anatomy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

open access

Vol 77, No 3 (2018)
ORIGINAL ARTICLES
Submitted: 2017-07-18
Accepted: 2017-11-10
Published online: 2017-11-27

Abstract

Background: Periodontal tissue remnants of odontogenesis constitute the dental follicle (DF) which is actually considered a stem niche in adults. However, potentialities of local endothelia within this niche seem overlooked. We thus aimed at testing the endothelial cells expression of c-kit, the progenitor cells marker, and CD68, commonly regarded as a monocyte/macrophage marker, in human DFs.
Materials and methods: We performed an immunohistochemical study using these two markers which were applied on samples collected from ten adult patients.
Results: The markers were positively expressed in endothelial cells, as well as in spindle-shaped stromal cells of the DF.
Conclusions: The origin of DF stem or progenitor cells needs reviewing in the light of these findings, as endothelium could be a donor site for niche inhabitants.

Abstract

Background: Periodontal tissue remnants of odontogenesis constitute the dental follicle (DF) which is actually considered a stem niche in adults. However, potentialities of local endothelia within this niche seem overlooked. We thus aimed at testing the endothelial cells expression of c-kit, the progenitor cells marker, and CD68, commonly regarded as a monocyte/macrophage marker, in human DFs.
Materials and methods: We performed an immunohistochemical study using these two markers which were applied on samples collected from ten adult patients.
Results: The markers were positively expressed in endothelial cells, as well as in spindle-shaped stromal cells of the DF.
Conclusions: The origin of DF stem or progenitor cells needs reviewing in the light of these findings, as endothelium could be a donor site for niche inhabitants.

Get Citation

Keywords

stem niche; dental stem cells; monocytes; CD117; immunohistochemistry

About this article
Title

Endothelial expression of c-kit and CD68 in dental follicles of human impacted third molars

Journal

Folia Morphologica

Issue

Vol 77, No 3 (2018)

Article type

Original article

Pages

485-488

Published online

2017-11-27

Page views

2142

Article views/downloads

1117

DOI

10.5603/FM.a2017.0108

Pubmed

29235086

Bibliographic record

Folia Morphol 2018;77(3):485-488.

Keywords

stem niche
dental stem cells
monocytes
CD117
immunohistochemistry

Authors

M. C. Rusu
A. Rașcu
M. D. Stoenescu

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