open access
Immunophilin ligands in peripheral nerve regeneration
open access
Abstract
Immunophilins are a family of receptors for immunosuppressive drugs like cyclosporin A, FK506, rapamycin and their non-immunosuppressive analogues, which are collectively referred to as immunophilin ligands. The present study aimed to review neuroprotective and neuroregenerative actions of immunophilin ligands on peripheral nerve injuries. The special emphasis was given to well-known immunosuppressive drug FK506. Its historical background, administration routes, dosages, neuroregenerative, neuroprotective actions, therapeutic time window in administration, action mechanism and side effects of FK506 were reviewed.
Abstract
Immunophilins are a family of receptors for immunosuppressive drugs like cyclosporin A, FK506, rapamycin and their non-immunosuppressive analogues, which are collectively referred to as immunophilin ligands. The present study aimed to review neuroprotective and neuroregenerative actions of immunophilin ligands on peripheral nerve injuries. The special emphasis was given to well-known immunosuppressive drug FK506. Its historical background, administration routes, dosages, neuroregenerative, neuroprotective actions, therapeutic time window in administration, action mechanism and side effects of FK506 were reviewed.
Keywords
immunophilins, FK506, cyclosporin A, rapamycin, peripheral nerve
Title
Immunophilin ligands in peripheral nerve regeneration
Journal
Issue
Article type
Review article
Pages
407-413
Published online
2015-11-26
Page views
1242
Article views/downloads
1837
DOI
10.5603/FM.2015.0100
Pubmed
Bibliographic record
Folia Morphol 2015;74(4):407-413.
Keywords
immunophilins
FK506
cyclosporin A
rapamycin
peripheral nerve
Authors
Y. Behram Kandemir
L. Sarikcioglu