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The temperature of caffeine administered during pregnancy and foetal morphometric parameters
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Abstract
Background: Caffeine is one of the most frequently ingested (at various temperatures) xenobiotics by people. A number of studies have confirmed the negative effect of high doses of caffeine ingested during pregnancy both for the mother and the developing foetus. The aim of this study was to evaluate the relationship between caffeine’s toxicity on development and the administered solution’stemperature.
Materials and methods: The research was conducted on rats. The fertilised females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30 mg/day) in10 (E1), 25 (E2) and 45°C (E3). The females in the control group were given water at the same temperature (C1, C2 and C3). On the 21st day of pregnancy, the pregnant females were killed by decapitation using a specially prepared laboratory guillotine and were assessed morphometric parameters of foetuses.
Results and Conclusions: Based on this work showed that: the embryotoxic effect of caffeine was only confined to a reduction in the number of offspring; the greatest changes in the morphometric parameters occurred in foetuses whose mothers received caffeine at 10°C; in the control groups, the greatest changes were observed in foetuses whose mothers were given water at 10°C during pregnancy.
Abstract
Background: Caffeine is one of the most frequently ingested (at various temperatures) xenobiotics by people. A number of studies have confirmed the negative effect of high doses of caffeine ingested during pregnancy both for the mother and the developing foetus. The aim of this study was to evaluate the relationship between caffeine’s toxicity on development and the administered solution’stemperature.
Materials and methods: The research was conducted on rats. The fertilised females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30 mg/day) in10 (E1), 25 (E2) and 45°C (E3). The females in the control group were given water at the same temperature (C1, C2 and C3). On the 21st day of pregnancy, the pregnant females were killed by decapitation using a specially prepared laboratory guillotine and were assessed morphometric parameters of foetuses.
Results and Conclusions: Based on this work showed that: the embryotoxic effect of caffeine was only confined to a reduction in the number of offspring; the greatest changes in the morphometric parameters occurred in foetuses whose mothers received caffeine at 10°C; in the control groups, the greatest changes were observed in foetuses whose mothers were given water at 10°C during pregnancy.
Keywords
caffeine, morphometric parameters, pregnancy, foetus, resorbed foetuses, post-implantation mortality
About this articleTitle
The temperature of caffeine administered during pregnancy and foetal morphometric parameters
Journal
Issue
Article type
Original article
Pages
347-352
Published online
2014-09-05
Page views
893
Article views/downloads
1481
DOI
10.5603/FM.2014.0051
Bibliographic record
Folia Morphol 2014;73(3):347-352.
Keywords
caffeine
morphometric parameters
pregnancy
foetus
resorbed foetuses
post-implantation mortality
Authors
M. Tomaszewski
F. Burdan
G. Olchowik
M. Tomaszewska
