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Human adult dental pulp CD117/c-kit-positive networks of stromal cells
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Abstract
Dental pulp tissue was collected from 6 healthy adult patients, prior to prosthetic treatments, in order to evaluate the in situ phenotype of dental pulp stromal cells and compare with that of dental pulp stem cells. A CD34–/CD44+/CD105–/CD117+/CD146–/nestin– phenotype of stromal cells in the dental pulp core was found. Cells with a similar phenotype, but CD44–, were found in the cell richzone. Dental pulp stromal networks (DPSNs) were found CD117+/CD44+ in the pulp core, but CD117+/CD44– in the cell rich zone. The c-kit-positive DPSNs were contacting pulp nerves and were, in this regard only, comparable to interstitial Cajal cells. Stromal signalling in dental pulp needs further evaluation, in normal tissue as well as a possible cause of persisting pain after endodontic treatments
Abstract
Dental pulp tissue was collected from 6 healthy adult patients, prior to prosthetic treatments, in order to evaluate the in situ phenotype of dental pulp stromal cells and compare with that of dental pulp stem cells. A CD34–/CD44+/CD105–/CD117+/CD146–/nestin– phenotype of stromal cells in the dental pulp core was found. Cells with a similar phenotype, but CD44–, were found in the cell richzone. Dental pulp stromal networks (DPSNs) were found CD117+/CD44+ in the pulp core, but CD117+/CD44– in the cell rich zone. The c-kit-positive DPSNs were contacting pulp nerves and were, in this regard only, comparable to interstitial Cajal cells. Stromal signalling in dental pulp needs further evaluation, in normal tissue as well as a possible cause of persisting pain after endodontic treatments
Keywords
dental pulp stem cells (DPSC), cell rich zone, CD44, stem cells, interstitial Cajal cells-like, stem cells of human exfoliated deciduous teeth
About this articleTitle
Human adult dental pulp CD117/c-kit-positive networks of stromal cells
Journal
Issue
Article type
Original article
Pages
68-72
Published online
2014-02-28
Page views
1776
Article views/downloads
1770
DOI
10.5603/FM.2014.0009
Bibliographic record
Folia Morphol 2014;73(1):68-72.
Keywords
dental pulp stem cells (DPSC)
cell rich zone
CD44
stem cells
interstitial Cajal cells-like
stem cells of human exfoliated deciduous teeth
Authors
M. C. Rusu
C. Loreto
A. Sava
V. Mănoiu
A. C. Didilescu
