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Original article
Submitted: 2023-08-02
Accepted: 2023-10-23
Published online: 2023-10-31
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Comparative observations on the squamous-columnar junction of Von Ebner’s glandular duct at the bottom of vallate papillae in dogs, rats, mice and human

Xinyu Chen1234, Lin Luo1234, Pengning Chen1234, Guanxi Chen1234, Qizhang Yan1234, Bosen Zhou1234, Nengming Liu1234, Ping Ruan5, Dahai Yu6
·
Pubmed: 37957939
Affiliations
  1. College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, China
  2. Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China
  3. Guangxi Clinical Research Centre for Craniofacial Deformity, Nanning, China
  4. Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Nanning, China
  5. Department of Pathology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China
  6. Department of Stomatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

open access

Ahead of Print
ORIGINAL ARTICLES
Submitted: 2023-08-02
Accepted: 2023-10-23
Published online: 2023-10-31

Abstract

Background: This paper aims to comparatively observe similarities of squamous-columnar junction (SCJ) at the opening of Von Ebner's glandular ducts at the vallate papillae in dogs, mice, rats and humans, lay a foundation for the selection of the model in future study of the carcinogenesis in SCJ at vallate papillae. Materials and methods: The localization of the vallate papillae in three laboratory animals and humans was comparatively observed. The differences of SCJ at vallate papillae were comparatively observed by Alcian blue, immunohistochemistry and HE staining. Results: Anatomically, the canine vallate papillae were most similar to those of humans in location, whereas mice and rats only had a single, Ω-shaped, vallate papilla lying directly anterior to the posterior border of the intermolar eminence. In histology, the SCJ of dogs lacked a transition zone similar to that of the human SCJ, and there was glandular epithelium secreting acidic mucus at the opening of the rats’ Von Ebner's glandular ducts. All of this suggested that the histological structure of SCJ in rats and dogs is more distinct from that of humans, whereas the histological structure of SCJ at vallate papilla in mice was more similar. Conclusions: The structure of SCJ at vallate papilla in mice is most similar to that of humans, so we conclude that mouse is the most suitable model for studying tumorigenesis in SCJ at vallate papillae in these three common laboratory animals.

Abstract

Background: This paper aims to comparatively observe similarities of squamous-columnar junction (SCJ) at the opening of Von Ebner's glandular ducts at the vallate papillae in dogs, mice, rats and humans, lay a foundation for the selection of the model in future study of the carcinogenesis in SCJ at vallate papillae. Materials and methods: The localization of the vallate papillae in three laboratory animals and humans was comparatively observed. The differences of SCJ at vallate papillae were comparatively observed by Alcian blue, immunohistochemistry and HE staining. Results: Anatomically, the canine vallate papillae were most similar to those of humans in location, whereas mice and rats only had a single, Ω-shaped, vallate papilla lying directly anterior to the posterior border of the intermolar eminence. In histology, the SCJ of dogs lacked a transition zone similar to that of the human SCJ, and there was glandular epithelium secreting acidic mucus at the opening of the rats’ Von Ebner's glandular ducts. All of this suggested that the histological structure of SCJ in rats and dogs is more distinct from that of humans, whereas the histological structure of SCJ at vallate papilla in mice was more similar. Conclusions: The structure of SCJ at vallate papilla in mice is most similar to that of humans, so we conclude that mouse is the most suitable model for studying tumorigenesis in SCJ at vallate papillae in these three common laboratory animals.

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Keywords

squamous-columnar junction (SCJ), Von Ebner' s glands, Vallate papillae

About this article
Title

Comparative observations on the squamous-columnar junction of Von Ebner’s glandular duct at the bottom of vallate papillae in dogs, rats, mice and human

Journal

Folia Morphologica

Issue

Ahead of Print

Article type

Original article

Published online

2023-10-31

Page views

142

Article views/downloads

116

DOI

10.5603/fm.96804

Pubmed

37957939

Keywords

squamous-columnar junction (SCJ)
Von Ebner's glands
Vallate papillae

Authors

Xinyu Chen
Lin Luo
Pengning Chen
Guanxi Chen
Qizhang Yan
Bosen Zhou
Nengming Liu
Ping Ruan
Dahai Yu

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