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Comparative observations on the squamous-columnar junction of Von Ebner’s glandular duct at the bottom of vallate papillae in dogs, rats, mice and human
, 1234, 1234, 1234, 1234, 1234, 1234, 5, 6
Affiliations- College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, China
- Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China
- Guangxi Clinical Research Centre for Craniofacial Deformity, Nanning, China
- Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Nanning, China
- Department of Pathology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China
- Department of Stomatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Abstract
Background: This paper aims to comparatively observe similarities of squamous-columnar junction (SCJ) at the opening of Von Ebner's glandular ducts at the vallate papillae in dogs, mice, rats and humans, lay a foundation for the selection of the model in future study of the carcinogenesis in SCJ at vallate papillae. Materials and methods: The localization of the vallate papillae in three laboratory animals and humans was comparatively observed. The differences of SCJ at vallate papillae were comparatively observed by Alcian blue, immunohistochemistry and HE staining. Results: Anatomically, the canine vallate papillae were most similar to those of humans in location, whereas mice and rats only had a single, Ω-shaped, vallate papilla lying directly anterior to the posterior border of the intermolar eminence. In histology, the SCJ of dogs lacked a transition zone similar to that of the human SCJ, and there was glandular epithelium secreting acidic mucus at the opening of the rats’ Von Ebner's glandular ducts. All of this suggested that the histological structure of SCJ in rats and dogs is more distinct from that of humans, whereas the histological structure of SCJ at vallate papilla in mice was more similar. Conclusions: The structure of SCJ at vallate papilla in mice is most similar to that of humans, so we conclude that mouse is the most suitable model for studying tumorigenesis in SCJ at vallate papillae in these three common laboratory animals.
Abstract
Background: This paper aims to comparatively observe similarities of squamous-columnar junction (SCJ) at the opening of Von Ebner's glandular ducts at the vallate papillae in dogs, mice, rats and humans, lay a foundation for the selection of the model in future study of the carcinogenesis in SCJ at vallate papillae. Materials and methods: The localization of the vallate papillae in three laboratory animals and humans was comparatively observed. The differences of SCJ at vallate papillae were comparatively observed by Alcian blue, immunohistochemistry and HE staining. Results: Anatomically, the canine vallate papillae were most similar to those of humans in location, whereas mice and rats only had a single, Ω-shaped, vallate papilla lying directly anterior to the posterior border of the intermolar eminence. In histology, the SCJ of dogs lacked a transition zone similar to that of the human SCJ, and there was glandular epithelium secreting acidic mucus at the opening of the rats’ Von Ebner's glandular ducts. All of this suggested that the histological structure of SCJ in rats and dogs is more distinct from that of humans, whereas the histological structure of SCJ at vallate papilla in mice was more similar. Conclusions: The structure of SCJ at vallate papilla in mice is most similar to that of humans, so we conclude that mouse is the most suitable model for studying tumorigenesis in SCJ at vallate papillae in these three common laboratory animals.
Keywords
squamous-columnar junction (SCJ), Von Ebner' s glands, Vallate papillae
About this articleTitle
Comparative observations on the squamous-columnar junction of Von Ebner’s glandular duct at the bottom of vallate papillae in dogs, rats, mice and human
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Original article
Published online
2023-10-31
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DOI
Pubmed
Keywords
squamous-columnar junction (SCJ)
Von Ebner's glands
Vallate papillae
Authors
Xinyu Chen
Lin Luo
Pengning Chen
Guanxi Chen
Qizhang Yan
Bosen Zhou
Nengming Liu
Ping Ruan
Dahai Yu
