open access

Vol 82, No 2 (2023)
Original article
Submitted: 2021-12-22
Accepted: 2022-01-28
Published online: 2022-02-28
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Quantitative study of the primary ossification centre of the parietal bone in the human fetus

M. Grzonkowska1, M. Baumgart1, M. Badura1, M. Wiśniewski1, M. Szpinda1
·
Pubmed: 35239181
·
Folia Morphol 2023;82(2):307-314.
Affiliations
  1. Department of Normal Anatomy, the Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Torun, Poland

open access

Vol 82, No 2 (2023)
ORIGINAL ARTICLES
Submitted: 2021-12-22
Accepted: 2022-01-28
Published online: 2022-02-28

Abstract

Background: Detailed morphometric data concentrating on the development of
primary ossification centres in human fetuses is critical for the early detection of
developmental defects. Thus, an understanding of the growth and development
of the parietal bone is crucial in assessing both the normal and pathological
development of the calvaria.
Materials and methods: The size of the parietal primary ossification centre in
37 spontaneously aborted human fetuses of both sexes (16 males and 21 females)
aged 18–30 weeks was studied by means of computed tomography, digital-image
analysis and statistics.
Results: The numerical data of the parietal primary ossification centre in the human
fetus displays neither sex nor laterality differences. With relation to fetal age in
weeks, the parietal primary ossification centre grew in sagittal diameter according
to the quadratic function: y = 16.322 + 0.0347 × (age)2 ± 1.323 (R2 = 0.96), in
projection surface area according to the cubic function: y = 284.1895 + 0.051 ×
× (age)3 ± 0.490, while in both coronal diameter and volume according to the
quartic functions: y = 21.746 + 0.000025 × (age)4 ± 1.256 and y = 296.984 +
+ 0.001 × (age)4, respectively.
Conclusions: The obtained morphometric data of the parietal primary ossification
centre may be considered age-specific references, and so may contribute to
the estimation of gestational ages and be useful in the diagnostics of congenital
cranial defects.

Abstract

Background: Detailed morphometric data concentrating on the development of
primary ossification centres in human fetuses is critical for the early detection of
developmental defects. Thus, an understanding of the growth and development
of the parietal bone is crucial in assessing both the normal and pathological
development of the calvaria.
Materials and methods: The size of the parietal primary ossification centre in
37 spontaneously aborted human fetuses of both sexes (16 males and 21 females)
aged 18–30 weeks was studied by means of computed tomography, digital-image
analysis and statistics.
Results: The numerical data of the parietal primary ossification centre in the human
fetus displays neither sex nor laterality differences. With relation to fetal age in
weeks, the parietal primary ossification centre grew in sagittal diameter according
to the quadratic function: y = 16.322 + 0.0347 × (age)2 ± 1.323 (R2 = 0.96), in
projection surface area according to the cubic function: y = 284.1895 + 0.051 ×
× (age)3 ± 0.490, while in both coronal diameter and volume according to the
quartic functions: y = 21.746 + 0.000025 × (age)4 ± 1.256 and y = 296.984 +
+ 0.001 × (age)4, respectively.
Conclusions: The obtained morphometric data of the parietal primary ossification
centre may be considered age-specific references, and so may contribute to
the estimation of gestational ages and be useful in the diagnostics of congenital
cranial defects.

Get Citation

Keywords

parietal bone, bone development, osteogenesis, fetal development

About this article
Title

Quantitative study of the primary ossification centre of the parietal bone in the human fetus

Journal

Folia Morphologica

Issue

Vol 82, No 2 (2023)

Article type

Original article

Pages

307-314

Published online

2022-02-28

Page views

2158

Article views/downloads

851

DOI

10.5603/FM.a2022.0020

Pubmed

35239181

Bibliographic record

Folia Morphol 2023;82(2):307-314.

Keywords

parietal bone
bone development
osteogenesis
fetal development

Authors

M. Grzonkowska
M. Baumgart
M. Badura
M. Wiśniewski
M. Szpinda

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