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Quantitative study of the primary ossification centre of the parietal bone in the human fetus
, 1, 1, 1, 1
Affiliations- Department of Normal Anatomy, the Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Torun, Poland
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Abstract
Background: Detailed morphometric data concentrating on the development of
primary ossification centres in human fetuses is critical for the early detection of
developmental defects. Thus, an understanding of the growth and development
of the parietal bone is crucial in assessing both the normal and pathological
development of the calvaria.
Materials and methods: The size of the parietal primary ossification centre in
37 spontaneously aborted human fetuses of both sexes (16 males and 21 females)
aged 18–30 weeks was studied by means of computed tomography, digital-image
analysis and statistics.
Results: The numerical data of the parietal primary ossification centre in the human
fetus displays neither sex nor laterality differences. With relation to fetal age in
weeks, the parietal primary ossification centre grew in sagittal diameter according
to the quadratic function: y = 16.322 + 0.0347 × (age)2 ± 1.323 (R2 = 0.96), in
projection surface area according to the cubic function: y = 284.1895 + 0.051 ×
× (age)3 ± 0.490, while in both coronal diameter and volume according to the
quartic functions: y = 21.746 + 0.000025 × (age)4 ± 1.256 and y = 296.984 +
+ 0.001 × (age)4, respectively.
Conclusions: The obtained morphometric data of the parietal primary ossification
centre may be considered age-specific references, and so may contribute to
the estimation of gestational ages and be useful in the diagnostics of congenital
cranial defects.
Abstract
Background: Detailed morphometric data concentrating on the development of
primary ossification centres in human fetuses is critical for the early detection of
developmental defects. Thus, an understanding of the growth and development
of the parietal bone is crucial in assessing both the normal and pathological
development of the calvaria.
Materials and methods: The size of the parietal primary ossification centre in
37 spontaneously aborted human fetuses of both sexes (16 males and 21 females)
aged 18–30 weeks was studied by means of computed tomography, digital-image
analysis and statistics.
Results: The numerical data of the parietal primary ossification centre in the human
fetus displays neither sex nor laterality differences. With relation to fetal age in
weeks, the parietal primary ossification centre grew in sagittal diameter according
to the quadratic function: y = 16.322 + 0.0347 × (age)2 ± 1.323 (R2 = 0.96), in
projection surface area according to the cubic function: y = 284.1895 + 0.051 ×
× (age)3 ± 0.490, while in both coronal diameter and volume according to the
quartic functions: y = 21.746 + 0.000025 × (age)4 ± 1.256 and y = 296.984 +
+ 0.001 × (age)4, respectively.
Conclusions: The obtained morphometric data of the parietal primary ossification
centre may be considered age-specific references, and so may contribute to
the estimation of gestational ages and be useful in the diagnostics of congenital
cranial defects.
Keywords
parietal bone, bone development, osteogenesis, fetal development
About this articleTitle
Quantitative study of the primary ossification centre of the parietal bone in the human fetus
Journal
Issue
Article type
Original article
Pages
307-314
Published online
2022-02-28
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2246
Article views/downloads
901
DOI
Pubmed
Bibliographic record
Folia Morphol 2023;82(2):307-314.
Keywords
parietal bone
bone development
osteogenesis
fetal development
Authors
M. Grzonkowska
M. Baumgart
M. Badura
M. Wiśniewski
M. Szpinda
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