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Original article
Submitted: 2021-12-22
Accepted: 2022-01-28
Published online: 2022-02-28
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Quantitative study of the primary ossification center of the parietal bone in the human fetus

M. Grzonkowska1, M. Baumgart1, M. Badura1, M. Wiśniewski1, M. Szpinda1
DOI: 10.5603/FM.a2022.0020
·
Pubmed: 35239181
Affiliations
  1. Department of Normal Anatomy, the Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Torun, Poland

open access

Ahead of Print
ORIGINAL ARTICLES
Submitted: 2021-12-22
Accepted: 2022-01-28
Published online: 2022-02-28

Abstract

Detailed morphometric data concentrating on the development of primary ossification centers in human fetuses is critical for the early detection of developmental defects. Thus, an understanding of the growth and development of the parietal bone is crucial in assessing both the normal and pathological development of the calvaria. The size of  the parietal primary ossification center in 37 spontaneously aborted human fetuses of both sexes (16 males and 21 females) aged 18–30 weeks was studied by means of CT, digital-image analysis and statistics. The numerical data of the parietal primary ossification center in the human fetus displays neither sex nor laterality differences. With relation to fetal age in weeks, the parietal primary ossification center grew in sagittal diameter according to the quadratic function y = 16.322 + 0.0347 × (age)2 ± 1.323 R2 = 0.96,  in projection surface area according to the cubic function
y = 284.1895 + 0.051 × (age)3 ± 0.490, while in both coronal diameter and volume according to the quartic functions: y = 21.746 + 0.000025 × (age)4 ± 1.256 and y = 296.984 + 0.001 × (age)4, respectively. The obtained morphometric data of the parietal primary ossification center may be considered age-specific references, and so may contribute to the estimation of gestational ages and be useful in the diagnostics of congenital cranial defects.

Abstract

Detailed morphometric data concentrating on the development of primary ossification centers in human fetuses is critical for the early detection of developmental defects. Thus, an understanding of the growth and development of the parietal bone is crucial in assessing both the normal and pathological development of the calvaria. The size of  the parietal primary ossification center in 37 spontaneously aborted human fetuses of both sexes (16 males and 21 females) aged 18–30 weeks was studied by means of CT, digital-image analysis and statistics. The numerical data of the parietal primary ossification center in the human fetus displays neither sex nor laterality differences. With relation to fetal age in weeks, the parietal primary ossification center grew in sagittal diameter according to the quadratic function y = 16.322 + 0.0347 × (age)2 ± 1.323 R2 = 0.96,  in projection surface area according to the cubic function
y = 284.1895 + 0.051 × (age)3 ± 0.490, while in both coronal diameter and volume according to the quartic functions: y = 21.746 + 0.000025 × (age)4 ± 1.256 and y = 296.984 + 0.001 × (age)4, respectively. The obtained morphometric data of the parietal primary ossification center may be considered age-specific references, and so may contribute to the estimation of gestational ages and be useful in the diagnostics of congenital cranial defects.

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Keywords

parietal bone, bone development, osteogenesis, fetal development

About this article
Title

Quantitative study of the primary ossification center of the parietal bone in the human fetus

Journal

Folia Morphologica

Issue

Ahead of Print

Article type

Original article

Published online

2022-02-28

Page views

252

Article views/downloads

169

DOI

10.5603/FM.a2022.0020

Pubmed

35239181

Keywords

parietal bone
bone development
osteogenesis
fetal development

Authors

M. Grzonkowska
M. Baumgart
M. Badura
M. Wiśniewski
M. Szpinda

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