open access

Vol 80, No 4 (2021)
Review article
Submitted: 2021-08-20
Accepted: 2021-09-10
Published online: 2021-09-15
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Can the kisspeptin help us in the understanding of pathology of some neurodegenerative brain diseases?

N. Melka1, A. Pszczolinska1, I. Klejbor23, B. Ludkiewicz1, P. Kowiański13, J. Moryś34
·
Pubmed: 34545559
·
Folia Morphol 2021;80(4):756-765.
Affiliations
  1. Department of Anatomy and Neurobiology, Faculty of Medicine, Medical University of Gdansk, Poland
  2. Department of Anatomy, Jan Kochanowski University of Kielce, Poland
  3. Department of Clinical Anatomy and Physiology, Institute of Health Sciences, Pomeranian University of Slupsk, Poland
  4. Department of Normal Anatomy, Faculty of Medicine and Dentistry, Pomeranian Medical University in Szczecin, Poland

open access

Vol 80, No 4 (2021)
REVIEW ARTICLES
Submitted: 2021-08-20
Accepted: 2021-09-10
Published online: 2021-09-15

Abstract

It is already known that the discovery of kisspeptin was a revolutionary step in the understanding of neuroendocrine regulation of reproduction. Kisspeptin is one of the main moderators of the gonadotropic axis, but the kisspeptin gene is known to be expressed in various regions of the central nervous system. The activity of kisspeptin is not limited to hypothalamic pituitary gonadal axis; it participates in the regulation of multiple neuronal circuits in the limbic system. The limbic system is a part of the brain involved in behavioural and emotional reactions, and disturbances in its functioning may be the source of some psychiatric as well as degenerative disorders. In the present review, we summarise the current state of knowledge concerning the role of kisspeptin in the limbic system and a new hope for the treatment of disturbances in its functioning.

Abstract

It is already known that the discovery of kisspeptin was a revolutionary step in the understanding of neuroendocrine regulation of reproduction. Kisspeptin is one of the main moderators of the gonadotropic axis, but the kisspeptin gene is known to be expressed in various regions of the central nervous system. The activity of kisspeptin is not limited to hypothalamic pituitary gonadal axis; it participates in the regulation of multiple neuronal circuits in the limbic system. The limbic system is a part of the brain involved in behavioural and emotional reactions, and disturbances in its functioning may be the source of some psychiatric as well as degenerative disorders. In the present review, we summarise the current state of knowledge concerning the role of kisspeptin in the limbic system and a new hope for the treatment of disturbances in its functioning.

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Keywords

kisspeptin, hypothalamus, limbic system, neurodegenerative disease

About this article
Title

Can the kisspeptin help us in the understanding of pathology of some neurodegenerative brain diseases?

Journal

Folia Morphologica

Issue

Vol 80, No 4 (2021)

Article type

Review article

Pages

756-765

Published online

2021-09-15

Page views

6894

Article views/downloads

1173

DOI

10.5603/FM.a2021.0090

Pubmed

34545559

Bibliographic record

Folia Morphol 2021;80(4):756-765.

Keywords

kisspeptin
hypothalamus
limbic system
neurodegenerative disease

Authors

N. Melka
A. Pszczolinska
I. Klejbor
B. Ludkiewicz
P. Kowiański
J. Moryś

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