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Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-02-13
Submitted: 2019-12-13
Accepted: 2020-01-23
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Effect of vitamin B17 on experimentally induced colon cancer in adult male albino rat

W. Badr El-Kholy, S. A. Abdel-Rahman, F. E.-N. Abd El-Hady El-Safti, N. Mohey Issa
DOI: 10.5603/FM.a2020.0021
·
Pubmed: 32073131

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-02-13
Submitted: 2019-12-13
Accepted: 2020-01-23

Abstract

Colon cancer is considered to be the third most common cancer worldwide. At diagnosis of colon cancer, 3.7-11% developed bone metastasis. Diet based strategies are important for prevention and treatment of colon cancer. This study investigated the effect of vitamin B17 on a DMH induced rat model of colon cancer. Eighty young adult male albino rats were divided into five groups. Group I (control group), Group II (vitamin B17), Group III (CC), Group IV (protected) and Group V (treated). Distal colon sections were prepared for light & scanning electron microscopic examination. Lumbar vertebrae specimens were prepared for light microscopic study. Morphometric and statistical analysis were done. In comparison with the control, both CC & treated groups showed invasion of the colonic tissue by pleomorphic branching colonic glands of variable shapes and sizes lined with dysplastic elongated hyperchromatic nuclei with frequent mitotic figures or stratified multilayered crowded nuclei with an extremely significant (p˂0.0001) reduction of goblet cell number when compared to the control together with major pathological bone changes were observed in cc and the treated groups. While the protected group showed impressive improvement of all previously mentioned diameters.

Abstract

Colon cancer is considered to be the third most common cancer worldwide. At diagnosis of colon cancer, 3.7-11% developed bone metastasis. Diet based strategies are important for prevention and treatment of colon cancer. This study investigated the effect of vitamin B17 on a DMH induced rat model of colon cancer. Eighty young adult male albino rats were divided into five groups. Group I (control group), Group II (vitamin B17), Group III (CC), Group IV (protected) and Group V (treated). Distal colon sections were prepared for light & scanning electron microscopic examination. Lumbar vertebrae specimens were prepared for light microscopic study. Morphometric and statistical analysis were done. In comparison with the control, both CC & treated groups showed invasion of the colonic tissue by pleomorphic branching colonic glands of variable shapes and sizes lined with dysplastic elongated hyperchromatic nuclei with frequent mitotic figures or stratified multilayered crowded nuclei with an extremely significant (p˂0.0001) reduction of goblet cell number when compared to the control together with major pathological bone changes were observed in cc and the treated groups. While the protected group showed impressive improvement of all previously mentioned diameters.

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Keywords

colon cancer rat, vitamin B17

About this article
Title

Effect of vitamin B17 on experimentally induced colon cancer in adult male albino rat

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2020-02-13

DOI

10.5603/FM.a2020.0021

Pubmed

32073131

Keywords

colon cancer rat
vitamin B17

Authors

W. Badr El-Kholy
S. A. Abdel-Rahman
F. E.-N. Abd El-Hady El-Safti
N. Mohey Issa

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