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Ahead of Print
ORIGINAL ARTICLES
Published online: 2019-12-03
Submitted: 2019-11-19
Accepted: 2019-11-21
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Features and clinical significance of the ossification centers in the odontoid process based on micro-computed tomography

Wei Wang, Xing Wang, Xiaoyan Ren, Zhijun Li, Baoke Su, Yangyang Xu, Xuebin Xu, Dongchen Lv, Wentao Liu, Shaojie Zhang, Lianxiang Chen, Xiaohe Li
DOI: 10.5603/FM.a2019.0130
·
Pubmed: 31802474

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2019-12-03
Submitted: 2019-11-19
Accepted: 2019-11-21

Abstract

Background: Microscopic structures of the ossification centers of the odontoid process were studied from the micro-CT images of the axis, and the potential influence of the ossification centers with different microscopic structures on odontoid process fractures was analyzed. Materials and methods: Eighteen odontoid process specimens were randomly collected and scanned by micro-CT. The obtained images were then input into the software for further observation and measurement. Incomplete absorption of the ossification centers in the base was observed, along with the anatomic structure of the regions with incomplete ossification and structural parameters of the trabecular bones. Results: The microscopic structures of the trabecular bones in the ossification centers in the base of the odontoid process could be clearly visualized from the micro-CT images. Among the 18 odontoid process specimens, 11 specimens were found with incomplete absorption of the ossification centers in the axis, the prevalence reaching up to 61%. Regions with incomplete ossification varied in size and morphology, and their 3D morphology was predominantly oval. Of all structural parameters examined for the trabecular bones, there were only significant differences in the degree of anisotropy (DA) between the regions with incomplete absorption of ossification centers and the average vertebral trabecular bones (P < 0.05). Conclusions: Incomplete absorption of the ossification centers in the base of the odontoid process is a relatively prevalent condition. The cavitation effect of the trabecular bones may be the primary cause for odontoid process fractures.

Abstract

Background: Microscopic structures of the ossification centers of the odontoid process were studied from the micro-CT images of the axis, and the potential influence of the ossification centers with different microscopic structures on odontoid process fractures was analyzed. Materials and methods: Eighteen odontoid process specimens were randomly collected and scanned by micro-CT. The obtained images were then input into the software for further observation and measurement. Incomplete absorption of the ossification centers in the base was observed, along with the anatomic structure of the regions with incomplete ossification and structural parameters of the trabecular bones. Results: The microscopic structures of the trabecular bones in the ossification centers in the base of the odontoid process could be clearly visualized from the micro-CT images. Among the 18 odontoid process specimens, 11 specimens were found with incomplete absorption of the ossification centers in the axis, the prevalence reaching up to 61%. Regions with incomplete ossification varied in size and morphology, and their 3D morphology was predominantly oval. Of all structural parameters examined for the trabecular bones, there were only significant differences in the degree of anisotropy (DA) between the regions with incomplete absorption of ossification centers and the average vertebral trabecular bones (P < 0.05). Conclusions: Incomplete absorption of the ossification centers in the base of the odontoid process is a relatively prevalent condition. The cavitation effect of the trabecular bones may be the primary cause for odontoid process fractures.

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Keywords

odontoid process, ossification center, micro-CT, cavitation effect

About this article
Title

Features and clinical significance of the ossification centers in the odontoid process based on micro-computed tomography

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2019-12-03

DOI

10.5603/FM.a2019.0130

Pubmed

31802474

Keywords

odontoid process
ossification center
micro-CT
cavitation effect

Authors

Wei Wang
Xing Wang
Xiaoyan Ren
Zhijun Li
Baoke Su
Yangyang Xu
Xuebin Xu
Dongchen Lv
Wentao Liu
Shaojie Zhang
Lianxiang Chen
Xiaohe Li

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