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ORIGINAL ARTICLES
Published online: 2020-02-05
Submitted: 2019-10-29
Accepted: 2019-12-30
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Development of the interatrial wall during the ontogenesis of foetuses and children up to 1 year of age

R. Kamiński, A. Kosiński, A. Kaczyńska, M. Zajączkowski, G. Piwko, M. Gleinert-Rożek, T. Gos, K. Karnecki
DOI: 10.5603/FM.a2020.0009
·
Pubmed: 32020578

open access

Ahead of Print
ORIGINAL ARTICLES
Published online: 2020-02-05
Submitted: 2019-10-29
Accepted: 2019-12-30

Abstract

Background. The foramen ovale, present in foetal interatrial septum, plays an important role during foetal life. During delivery, foramen ovale closes and becomes fossa ovalis, starting the pulmonary circulation. The aim of our study was to describe the growth of the interatrial wall and changes in location of the foramen ovale, and fossa ovalis during the ontogenesis in the human hearts. Methods. The study was performed on post-mortem material obtained from 92 human hearts from 22nd week of foetal life up to 1 year of age, fixed in a 4% formalin solution. Results. The interatrial wall size in the studied development period was greater in the horizontal than in the vertical dimension. During ontogenesis up to one year old, the anterior and inferior parts of the interatrial wall, increased their shares considerably by 8% and 6%, respectively. The percentage participation of foramen ovale in the interatrial wall construction in the foetal period, formed more than 50% of its size and fairly decreased reaching in infants about 39%. Conclusions. Our study demonstrated that during ontogenesis, from the foetal period to infancy, the parts of the interatrial wall increase their dimensions unevenly. The foramen ovale growth is smaller, compare to the rest of the interatrial wall development. On the basis of our data we can assume that the foramen ovale center tends to be found in the postero-inferior quadrant of the interatrial wall (foetuses) and in postero-superior quadrant of the interatrial wall - in infants.

Abstract

Background. The foramen ovale, present in foetal interatrial septum, plays an important role during foetal life. During delivery, foramen ovale closes and becomes fossa ovalis, starting the pulmonary circulation. The aim of our study was to describe the growth of the interatrial wall and changes in location of the foramen ovale, and fossa ovalis during the ontogenesis in the human hearts. Methods. The study was performed on post-mortem material obtained from 92 human hearts from 22nd week of foetal life up to 1 year of age, fixed in a 4% formalin solution. Results. The interatrial wall size in the studied development period was greater in the horizontal than in the vertical dimension. During ontogenesis up to one year old, the anterior and inferior parts of the interatrial wall, increased their shares considerably by 8% and 6%, respectively. The percentage participation of foramen ovale in the interatrial wall construction in the foetal period, formed more than 50% of its size and fairly decreased reaching in infants about 39%. Conclusions. Our study demonstrated that during ontogenesis, from the foetal period to infancy, the parts of the interatrial wall increase their dimensions unevenly. The foramen ovale growth is smaller, compare to the rest of the interatrial wall development. On the basis of our data we can assume that the foramen ovale center tends to be found in the postero-inferior quadrant of the interatrial wall (foetuses) and in postero-superior quadrant of the interatrial wall - in infants.

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Keywords

interatrial wall, foramen ovale, fossa ovalis, right atrium

About this article
Title

Development of the interatrial wall during the ontogenesis of foetuses and children up to 1 year of age

Journal

Folia Morphologica

Issue

Ahead of Print

Published online

2020-02-05

DOI

10.5603/FM.a2020.0009

Pubmed

32020578

Keywords

interatrial wall
foramen ovale
fossa ovalis
right atrium

Authors

R. Kamiński
A. Kosiński
A. Kaczyńska
M. Zajączkowski
G. Piwko
M. Gleinert-Rożek
T. Gos
K. Karnecki

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