open access

Vol 79, No 3 (2020)
ORIGINAL ARTICLES
Published online: 2019-09-03
Submitted: 2019-06-28
Accepted: 2019-08-27
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Aging changes of the testis in albino rat: light, electron microscopic, morphometric, immunohistochemical and biochemical study

S. M. Hussein, A. B. El-Fadaly, A. G. Metawea, B. E. A. Khaled
DOI: 10.5603/FM.a2019.0102
·
Pubmed: 31489605
·
Folia Morphol 2020;79(3):503-515.

open access

Vol 79, No 3 (2020)
ORIGINAL ARTICLES
Published online: 2019-09-03
Submitted: 2019-06-28
Accepted: 2019-08-27

Abstract

Background: Aging has a deleterious effect on the morphology of the male reproductive system which might, in turn, lead to changes in spermatogenesis and consequently, decrease in both quality and quantity of spermatozoa.

Materials and methods: The present study elucidated the histological and ultrastructural changes of testes of adult albino rats during aging and applied morphometric measures to obtain quantitative data for these changes. The oxidative and antioxidative markers of aged testes were also assessed.

Results: The results documented the presence of age-related regressive structural changes of the testis accompanied with an increase in the apoptosis and a decrease in the proliferative capacity.

Conclusions: The biochemical results gave evidence of an imbalance between the oxidative damage and the antioxidant defence indicating increased oxidative stress of aged testis.

Abstract

Background: Aging has a deleterious effect on the morphology of the male reproductive system which might, in turn, lead to changes in spermatogenesis and consequently, decrease in both quality and quantity of spermatozoa.

Materials and methods: The present study elucidated the histological and ultrastructural changes of testes of adult albino rats during aging and applied morphometric measures to obtain quantitative data for these changes. The oxidative and antioxidative markers of aged testes were also assessed.

Results: The results documented the presence of age-related regressive structural changes of the testis accompanied with an increase in the apoptosis and a decrease in the proliferative capacity.

Conclusions: The biochemical results gave evidence of an imbalance between the oxidative damage and the antioxidant defence indicating increased oxidative stress of aged testis.

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Keywords

aging, testis, morphological changes; oxidative markers; ultrastructure; proliferative cell nuclear antigen (PCNA); apoptosis (caspase-3)

About this article
Title

Aging changes of the testis in albino rat: light, electron microscopic, morphometric, immunohistochemical and biochemical study

Journal

Folia Morphologica

Issue

Vol 79, No 3 (2020)

Pages

503-515

Published online

2019-09-03

DOI

10.5603/FM.a2019.0102

Pubmed

31489605

Bibliographic record

Folia Morphol 2020;79(3):503-515.

Keywords

aging
testis
morphological changes
oxidative markers
ultrastructure
proliferative cell nuclear antigen (PCNA)
apoptosis (caspase-3)

Authors

S. M. Hussein
A. B. El-Fadaly
A. G. Metawea
B. E. A. Khaled

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