open access

Vol 79, No 2 (2020)
ORIGINAL ARTICLES
Published online: 2019-06-27
Submitted: 2019-02-21
Accepted: 2019-04-01
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Adverse effects of energy drink on rat pancreas and the therapeutic role of each of bone marrow mesenchymal stem cells and Nigella Sativa oil

H. Haroun, E. Mohamed, A. E. R. El Shahat, H. Labib, M. Atef
DOI: 10.5603/FM.a2019.0069
·
Pubmed: 31257565
·
Folia Morphol 2020;79(2):272-279.

open access

Vol 79, No 2 (2020)
ORIGINAL ARTICLES
Published online: 2019-06-27
Submitted: 2019-02-21
Accepted: 2019-04-01

Abstract

Background: Energy drinks have been observed to threaten public health leading to many medical problems. Bone marrow-derived mesenchymal stem cells (BMSCs) have broad prospects in tissue regeneration. Nigella Sativa (NS) possess great therapeutic properties for the treatment of a wide range of diseases.

Materials and methods: Forty adult male albino rats were divided into: control group and treated group. The treated group was further subdivided into: energy drink subgroup 2a, BMSCs-injected subgroup 2b, NS-injected subgroup 2c. Histological, immunohistochemical and biochemical assessment was performed.

Results: Administration of energy drink revealed that it adversely affected the pancreatic cytoarchitecture. BMSCs and NS have been similarly observed to significantly ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.

Conclusions: The extent of pancreatic regeneration, exerted by each of BMSCs and NS oil, is nearly similar but the effect of BMSCs is more superior; however, NS could be privileged to BMSCs as a line of treatment being easily accessible and of lower cost.

Abstract

Background: Energy drinks have been observed to threaten public health leading to many medical problems. Bone marrow-derived mesenchymal stem cells (BMSCs) have broad prospects in tissue regeneration. Nigella Sativa (NS) possess great therapeutic properties for the treatment of a wide range of diseases.

Materials and methods: Forty adult male albino rats were divided into: control group and treated group. The treated group was further subdivided into: energy drink subgroup 2a, BMSCs-injected subgroup 2b, NS-injected subgroup 2c. Histological, immunohistochemical and biochemical assessment was performed.

Results: Administration of energy drink revealed that it adversely affected the pancreatic cytoarchitecture. BMSCs and NS have been similarly observed to significantly ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.

Conclusions: The extent of pancreatic regeneration, exerted by each of BMSCs and NS oil, is nearly similar but the effect of BMSCs is more superior; however, NS could be privileged to BMSCs as a line of treatment being easily accessible and of lower cost.

Get Citation

Keywords

energy drink, pancreas, bone marrow derived mesenchymal stem cells, Nigella Sativa

About this article
Title

Adverse effects of energy drink on rat pancreas and the therapeutic role of each of bone marrow mesenchymal stem cells and Nigella Sativa oil

Journal

Folia Morphologica

Issue

Vol 79, No 2 (2020)

Pages

272-279

Published online

2019-06-27

DOI

10.5603/FM.a2019.0069

Pubmed

31257565

Bibliographic record

Folia Morphol 2020;79(2):272-279.

Keywords

energy drink
pancreas
bone marrow derived mesenchymal stem cells
Nigella Sativa

Authors

H. Haroun
E. Mohamed
A. E. R. El Shahat
H. Labib
M. Atef

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