Vol 78, No 1 (2019)
Original article
Published online: 2018-05-28
Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis
Abstract
Background: This examination was performed to research the advantage of the antioxidant impact of Potentilla fulgens on spinal cord injury (SCI) in rats.
Materials and methods: In the SCI model of this examination, the tolerably serious lesion was performed at the L1–L2 spinal segmental level. SCI animals were given P. fulgens 400 mg/kg/day, intraperitoneally. At 7 days post-lesion, exploratory rats were executed after intraperitoneal administration 7 ketamine HCL (0.15 mL/100 g body weight). Spinal cord specimens were taken for histological examination or assurance of malondialdehyde (MDA) and glutathione (GSH) levels and myelope- roxidase (MPO) action. SCI caused a remarkable decline in spinal cord GSH content, trailed by noteworthy increments in MDA levels and MPO action.
Results: Degenerative changes in some multipolar and bipolar nerve cells and pyknotic changes in the nuclei of glial cells were likewise noticed. Remarkable development was seen in cells and vascular structures of P. fulgens treated groups when contrasted with untreated groups.
Conclusions: Potentilla fulgens application may influence angiogenetic impro- vement in vein endothelial cells, reduce inflammatory cell aggregation by influ- encing cytokine system and may make apoptotic nerve cells and neuroprotective component in glial cells
Keywords: spinal cord injuryPotentilla fulgensvascular endothelial growth factor (VEGF)B-cell lymphoma 2 (Bcl-2)
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