open access

Vol 74, No 4 (2015)
REVIEW ARTICLES
Published online: 2015-11-26
Submitted: 2014-08-12
Accepted: 2014-10-25
Get Citation

Immunophilin ligands in peripheral nerve regeneration

Y. Behram Kandemir, L. Sarikcioglu
DOI: 10.5603/FM.2015.0100
·
Pubmed: 26620498
·
Folia Morphol 2015;74(4):407-413.

open access

Vol 74, No 4 (2015)
REVIEW ARTICLES
Published online: 2015-11-26
Submitted: 2014-08-12
Accepted: 2014-10-25

Abstract

Immunophilins are a family of receptors for immunosuppressive drugs like cyclo­sporin A, FK506, rapamycin and their non-immunosuppressive analogues, which are collectively referred to as immunophilin ligands. The present study aimed to review neuroprotective and neuroregenerative actions of immunophilin ligands on peripheral nerve injuries. The special emphasis was given to well-known immunosuppressive drug FK506. Its historical background, administration routes, dosages, neuroregenerative, neuroprotective actions, therapeutic time window in administration, action mechanism and side effects of FK506 were reviewed.

Abstract

Immunophilins are a family of receptors for immunosuppressive drugs like cyclo­sporin A, FK506, rapamycin and their non-immunosuppressive analogues, which are collectively referred to as immunophilin ligands. The present study aimed to review neuroprotective and neuroregenerative actions of immunophilin ligands on peripheral nerve injuries. The special emphasis was given to well-known immunosuppressive drug FK506. Its historical background, administration routes, dosages, neuroregenerative, neuroprotective actions, therapeutic time window in administration, action mechanism and side effects of FK506 were reviewed.

Get Citation

Keywords

immunophilins, FK506, cyclosporin A, rapamycin, peripheral nerve

About this article
Title

Immunophilin ligands in peripheral nerve regeneration

Journal

Folia Morphologica

Issue

Vol 74, No 4 (2015)

Pages

407-413

Published online

2015-11-26

DOI

10.5603/FM.2015.0100

Pubmed

26620498

Bibliographic record

Folia Morphol 2015;74(4):407-413.

Keywords

immunophilins
FK506
cyclosporin A
rapamycin
peripheral nerve

Authors

Y. Behram Kandemir
L. Sarikcioglu

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