open access

Vol 73, No 1 (2014)
ORIGINAL ARTICLES
Published online: 2014-02-28
Submitted: 2013-07-24
Accepted: 2013-09-13
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Human adult dental pulp CD117/c-kit-positive networks of stromal cells

M. C. Rusu, C. Loreto, A. Sava, V. Mănoiu, A. C. Didilescu
DOI: 10.5603/FM.2014.0009
·
Folia Morphol 2014;73(1):68-72.

open access

Vol 73, No 1 (2014)
ORIGINAL ARTICLES
Published online: 2014-02-28
Submitted: 2013-07-24
Accepted: 2013-09-13

Abstract

Dental pulp tissue was collected from 6 healthy adult patients, prior to prosthetic treatments, in order to evaluate the in situ phenotype of dental pulp stromal cells and compare with that of dental pulp stem cells. A CD34–/CD44+/CD105–/CD117+/CD146–/nestin– phenotype of stromal cells in the dental pulp core was found. Cells with a similar phenotype, but CD44–, were found in the cell richzone. Dental pulp stromal networks (DPSNs) were found CD117+/CD44+ in the pulp core, but CD117+/CD44– in the cell rich zone. The c-kit-positive DPSNs were contacting pulp nerves and were, in this regard only, comparable to interstitial Cajal cells. Stromal signalling in dental pulp needs further evaluation, in normal tissue as well as a possible cause of persisting pain after endodontic treatments

Abstract

Dental pulp tissue was collected from 6 healthy adult patients, prior to prosthetic treatments, in order to evaluate the in situ phenotype of dental pulp stromal cells and compare with that of dental pulp stem cells. A CD34–/CD44+/CD105–/CD117+/CD146–/nestin– phenotype of stromal cells in the dental pulp core was found. Cells with a similar phenotype, but CD44–, were found in the cell richzone. Dental pulp stromal networks (DPSNs) were found CD117+/CD44+ in the pulp core, but CD117+/CD44– in the cell rich zone. The c-kit-positive DPSNs were contacting pulp nerves and were, in this regard only, comparable to interstitial Cajal cells. Stromal signalling in dental pulp needs further evaluation, in normal tissue as well as a possible cause of persisting pain after endodontic treatments

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Keywords

dental pulp stem cells (DPSC), cell rich zone, CD44, stem cells, interstitial Cajal cells-like, stem cells of human exfoliated deciduous teeth

About this article
Title

Human adult dental pulp CD117/c-kit-positive networks of stromal cells

Journal

Folia Morphologica

Issue

Vol 73, No 1 (2014)

Pages

68-72

Published online

2014-02-28

DOI

10.5603/FM.2014.0009

Bibliographic record

Folia Morphol 2014;73(1):68-72.

Keywords

dental pulp stem cells (DPSC)
cell rich zone
CD44
stem cells
interstitial Cajal cells-like
stem cells of human exfoliated deciduous teeth

Authors

M. C. Rusu
C. Loreto
A. Sava
V. Mănoiu
A. C. Didilescu

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