open access

Vol 70, No 4 (2011)
ORIGINAL ARTICLES
Published online: 2011-11-25
Submitted: 2012-06-27
Get Citation

Morphometric characteristics of the small and large intestines of Mus musculus during postnatal development

K. Wołczuk, B. Wilczyńska, M. Jaroszewska, J. Kobak
Folia Morphol 2011;70(4):252-259.

open access

Vol 70, No 4 (2011)
ORIGINAL ARTICLES
Published online: 2011-11-25
Submitted: 2012-06-27

Abstract

The objective of this study was to investigate the size of the small and large intestine in postnatal development of Mus musculus mice. The gut was obtained from 2-, 4-, 6-, and 12-week-old animals. The morphometric analysis was performed at microscopic level. Measurements and calculations included dimensions of villi (height, diameter) and their number per 1 mm2 surface area in the proximal, middle, and distal section of the small intestine, as well as the length and surface area (external and internal) of the small and large intestines.
To find the allometric relationship between the size of the small and large intestines and body mass, reduced major axis regression was applied. The length and surface area of both intestinal segments gradually increased with age. The increase in the internal surface area of the small intestine was the result of lengthening of the intestine and increasing diameter of the villi in its proximal and middle sections. No increase in villus height during the studied period was detected. A marked increase in the size of the intestinal segments was observed between the 2nd and 4th weeks of life, when the length doubled and the surface area tripled in size. Allometric analysis revealed that the increase in length and internal surface area of the small and large intestines was more rapid than the body mass increase during the weaning period, while it was not different from isometry after the weaning. In conclusion, the greatest changes in the structure and size of the small and large intestines of mice occurred in the weaning period. During this period these two segments of intestine grew faster than the rest of the body and reached adult proportions. (Folia Morphol 2011; 70, 4: 252–259)

Abstract

The objective of this study was to investigate the size of the small and large intestine in postnatal development of Mus musculus mice. The gut was obtained from 2-, 4-, 6-, and 12-week-old animals. The morphometric analysis was performed at microscopic level. Measurements and calculations included dimensions of villi (height, diameter) and their number per 1 mm2 surface area in the proximal, middle, and distal section of the small intestine, as well as the length and surface area (external and internal) of the small and large intestines.
To find the allometric relationship between the size of the small and large intestines and body mass, reduced major axis regression was applied. The length and surface area of both intestinal segments gradually increased with age. The increase in the internal surface area of the small intestine was the result of lengthening of the intestine and increasing diameter of the villi in its proximal and middle sections. No increase in villus height during the studied period was detected. A marked increase in the size of the intestinal segments was observed between the 2nd and 4th weeks of life, when the length doubled and the surface area tripled in size. Allometric analysis revealed that the increase in length and internal surface area of the small and large intestines was more rapid than the body mass increase during the weaning period, while it was not different from isometry after the weaning. In conclusion, the greatest changes in the structure and size of the small and large intestines of mice occurred in the weaning period. During this period these two segments of intestine grew faster than the rest of the body and reached adult proportions. (Folia Morphol 2011; 70, 4: 252–259)
Get Citation

Keywords

mice intestine; postnatal growth; morphometry; allometry

About this article
Title

Morphometric characteristics of the small and large intestines of Mus musculus during postnatal development

Journal

Folia Morphologica

Issue

Vol 70, No 4 (2011)

Pages

252-259

Published online

2011-11-25

Bibliographic record

Folia Morphol 2011;70(4):252-259.

Keywords

mice intestine
postnatal growth
morphometry
allometry

Authors

K. Wołczuk
B. Wilczyńska
M. Jaroszewska
J. Kobak

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By  "Via Medica sp. z o.o." sp.k., Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl