open access

Vol 71, No 1 (2012)
ORIGINAL ARTICLES
Published online: 2012-04-19
Submitted: 2012-06-27
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Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa

I. Kasacka, W. Łebkowski, I. Janiuk, J. Łapińska, A. Lewandowska
Folia Morphol 2012;71(1):39-44.

open access

Vol 71, No 1 (2012)
ORIGINAL ARTICLES
Published online: 2012-04-19
Submitted: 2012-06-27

Abstract

The detailed description of the distribution of endocrine cells G and D producing important hormones that regulate activation of other cells in the human stomach may be a valuable source of information for opinions about mucosa changes in different diseases of the alimentary tract. The density and distribution of immunoreactive G and D cells in the pylorus of humans (donors of organs) were evaluated. The pylorus samples were collected after other organs were harvested for transplantation. The number of G cells in the pyloric mucosa of healthy people was higher than the number of D cells. G and D cells were distributed between columnar cells of epithelium mucosa. Multiform endocrine cells generally occurred: gastrin in the middle third of the mucosa and somatostatin cells in the basal half of the pyloric mucosa. The investigation of the pyloric part of the healthy human stomach showed a characteristic distribution of cells that reacted with antisera against gastrin and somatostatin.

Abstract

The detailed description of the distribution of endocrine cells G and D producing important hormones that regulate activation of other cells in the human stomach may be a valuable source of information for opinions about mucosa changes in different diseases of the alimentary tract. The density and distribution of immunoreactive G and D cells in the pylorus of humans (donors of organs) were evaluated. The pylorus samples were collected after other organs were harvested for transplantation. The number of G cells in the pyloric mucosa of healthy people was higher than the number of D cells. G and D cells were distributed between columnar cells of epithelium mucosa. Multiform endocrine cells generally occurred: gastrin in the middle third of the mucosa and somatostatin cells in the basal half of the pyloric mucosa. The investigation of the pyloric part of the healthy human stomach showed a characteristic distribution of cells that reacted with antisera against gastrin and somatostatin.
Get Citation

Keywords

G-cells; D-cells; immunohistochemistry; human pylorus

About this article
Title

Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa

Journal

Folia Morphologica

Issue

Vol 71, No 1 (2012)

Pages

39-44

Published online

2012-04-19

Bibliographic record

Folia Morphol 2012;71(1):39-44.

Keywords

G-cells
D-cells
immunohistochemistry
human pylorus

Authors

I. Kasacka
W. Łebkowski
I. Janiuk
J. Łapińska
A. Lewandowska

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