Vol 58, No 2 (1999)
Original article
Submitted: 2012-02-06
Published online: 2000-01-25
Long-term effect of neonatal monosodium glutamate (MSG) treatment on reproductive system of the female rat
Miśkowiak B, Kęsa B, Limanowski A, Patryka M, Filipiak B
Folia Morphol 1999;58(2):105-113.
Vol 58, No 2 (1999)
ORIGINAL ARTICLES
Submitted: 2012-02-06
Published online: 2000-01-25
Abstract
The study aimed at determining effects of monosodium glutamate (MSG), introduced in the perinatal period, on the reproductive system of .sexually mature female rats. ln days 2, 4, 6, 8, l0 the: newborns received s.c. injections of MSG (4 mg/g body weight) or2% NaCl solution. When the animals reached the age of 6, l2 or l8 months, their ovaries and uteri were isolated for histological and morphometric studies while in their sera estradiol level was estimated by the RIA technique. The perinatal injection of MSG was found to decrease relative weights of ovaries and uteri. In the ovaries increased numbers of primordial follicles and deceased numbers of graafian follicles were detected . Also the thickness of endometrium and of the epithelium, which lined the endometrium, were lowered in females, which received perinatal injections of MSG, as compared to the controls. Serum estradiol level in MSG injected females was lowered at the age of 12 and 18 month old females the alterations were accompanied by obesity and a decreased body length.
Abstract
The study aimed at determining effects of monosodium glutamate (MSG), introduced in the perinatal period, on the reproductive system of .sexually mature female rats. ln days 2, 4, 6, 8, l0 the: newborns received s.c. injections of MSG (4 mg/g body weight) or2% NaCl solution. When the animals reached the age of 6, l2 or l8 months, their ovaries and uteri were isolated for histological and morphometric studies while in their sera estradiol level was estimated by the RIA technique. The perinatal injection of MSG was found to decrease relative weights of ovaries and uteri. In the ovaries increased numbers of primordial follicles and deceased numbers of graafian follicles were detected . Also the thickness of endometrium and of the epithelium, which lined the endometrium, were lowered in females, which received perinatal injections of MSG, as compared to the controls. Serum estradiol level in MSG injected females was lowered at the age of 12 and 18 month old females the alterations were accompanied by obesity and a decreased body length.
Keywords
MSG. Monosodium glutamate. Ovary. Uterus. Oestradiol.
Title
Long-term effect of neonatal monosodium glutamate (MSG) treatment on reproductive system of the female rat
Journal
Folia Morphologica
Issue
Vol 58, No 2 (1999)
Article type
Original article
Pages
105-113
Published online
2000-01-25
Page views
896
Bibliographic record
Folia Morphol 1999;58(2):105-113.
Keywords
MSG. Monosodium glutamate. Ovary. Uterus. Oestradiol.
Authors
Miśkowiak B
Kęsa B
Limanowski A
Patryka M
Filipiak B
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