Vol 58, No 2 (1999)
ORIGINAL ARTICLES
Published online: 2000-01-25
Submitted: 2012-02-06
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Long-term effect of neonatal monosodium glutamate (MSG) treatment on reproductive system of the female rat

Miśkowiak B, Kęsa B, Limanowski A, Patryka M, Filipiak B
Folia Morphol 1999;58(2):105-113.
Vol 58, No 2 (1999)
ORIGINAL ARTICLES
Published online: 2000-01-25
Submitted: 2012-02-06

Abstract

The study aimed at determining effects of monosodium glutamate (MSG), introduced in the perinatal period, on the reproductive system of .sexually mature female rats. ln days 2, 4, 6, 8, l0 the: newborns received s.c. injections of MSG (4 mg/g body weight) or2% NaCl solution. When the animals reached the age of 6, l2 or l8 months, their ovaries and uteri were isolated for histological and morphometric studies while in their sera estradiol level was estimated by the RIA technique. The perinatal injection of MSG was found to decrease relative weights of ovaries and uteri. In the ovaries increased numbers of primordial follicles and deceased numbers of graafian follicles were detected . Also the thickness of endometrium and of the epithelium, which lined the endometrium, were lowered in females, which received perinatal injections of MSG, as compared to the controls. Serum estradiol level in MSG injected females was lowered at the age of 12 and 18 month old females the alterations were accompanied by obesity and a decreased body length.

Abstract

The study aimed at determining effects of monosodium glutamate (MSG), introduced in the perinatal period, on the reproductive system of .sexually mature female rats. ln days 2, 4, 6, 8, l0 the: newborns received s.c. injections of MSG (4 mg/g body weight) or2% NaCl solution. When the animals reached the age of 6, l2 or l8 months, their ovaries and uteri were isolated for histological and morphometric studies while in their sera estradiol level was estimated by the RIA technique. The perinatal injection of MSG was found to decrease relative weights of ovaries and uteri. In the ovaries increased numbers of primordial follicles and deceased numbers of graafian follicles were detected . Also the thickness of endometrium and of the epithelium, which lined the endometrium, were lowered in females, which received perinatal injections of MSG, as compared to the controls. Serum estradiol level in MSG injected females was lowered at the age of 12 and 18 month old females the alterations were accompanied by obesity and a decreased body length.
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Keywords

MSG. Monosodium glutamate. Ovary. Uterus. Oestradiol.

About this article
Title

Long-term effect of neonatal monosodium glutamate (MSG) treatment on reproductive system of the female rat

Journal

Folia Morphologica

Issue

Vol 58, No 2 (1999)

Pages

105-113

Published online

2000-01-25

Bibliographic record

Folia Morphol 1999;58(2):105-113.

Keywords

MSG. Monosodium glutamate. Ovary. Uterus. Oestradiol.

Authors

Miśkowiak B
Kęsa B
Limanowski A
Patryka M
Filipiak B

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