Glial line-derived neurotrophic factor (GDNF): Biological activities
Folia Morphol 1999;58(3):155-159.
Vol 58, No 3 (1999)
REVIEW ARTICLES
Submitted: 2012-02-06
Published online: 2000-05-15
Abstract
Glial cell line-derived neurotrophic factor (GDNF) was initially discovered as a neurotrophic factor that enhances survival of midbrain dopaminergic neurons. Findings in 1994 and 1995 extended the spectrum of biological activities of GDNF to different populations of neurons (motor and sensory). Recent findings revealed that GDNF, Neurturin (NTN), Persephin (PSP), and Artemin (ARTN) are members of the GDNF protein family and are structurally related to transforming growth factor protein family. They are survival factors for peripheral and central neurons, for oligodendrocytes and can promote morphogenesis of kidney in vitro.
Abstract
Glial cell line-derived neurotrophic factor (GDNF) was initially discovered as a neurotrophic factor that enhances survival of midbrain dopaminergic neurons. Findings in 1994 and 1995 extended the spectrum of biological activities of GDNF to different populations of neurons (motor and sensory). Recent findings revealed that GDNF, Neurturin (NTN), Persephin (PSP), and Artemin (ARTN) are members of the GDNF protein family and are structurally related to transforming growth factor protein family. They are survival factors for peripheral and central neurons, for oligodendrocytes and can promote morphogenesis of kidney in vitro.
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Keywords
Neurotrophic polypeptides. GDNF protein family. Survival factors for nervous system.
About this articleTitle
Glial line-derived neurotrophic factor (GDNF): Biological activities
Journal
Issue
Article type
Review article
Pages
155-159
Published online
2000-05-15
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489
Bibliographic record
Folia Morphol 1999;58(3):155-159.
Keywords
Neurotrophic polypeptides. GDNF protein family. Survival factors for nervous system.
Authors
Woźniak W
