Vol 58, No 3 (1999)
REVIEW ARTICLES
Published online: 2000-05-15
Submitted: 2012-02-06
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Glial line-derived neurotrophic factor (GDNF): Biological activities

Woźniak W
Folia Morphol 1999;58(3):155-159.
Vol 58, No 3 (1999)
REVIEW ARTICLES
Published online: 2000-05-15
Submitted: 2012-02-06

Abstract

Glial cell line-derived neurotrophic factor (GDNF) was initially discovered as a neurotrophic factor that enhances survival of midbrain dopaminergic neurons. Findings in 1994 and 1995 extended the spectrum of biological activities of GDNF to different populations of neurons (motor and sensory). Recent findings revealed that GDNF, Neurturin (NTN), Persephin (PSP), and Artemin (ARTN) are members of the GDNF protein family and are structurally related to transforming growth factor protein family. They are survival factors for peripheral and central neurons, for oligodendrocytes and can promote morphogenesis of kidney in vitro.

Abstract

Glial cell line-derived neurotrophic factor (GDNF) was initially discovered as a neurotrophic factor that enhances survival of midbrain dopaminergic neurons. Findings in 1994 and 1995 extended the spectrum of biological activities of GDNF to different populations of neurons (motor and sensory). Recent findings revealed that GDNF, Neurturin (NTN), Persephin (PSP), and Artemin (ARTN) are members of the GDNF protein family and are structurally related to transforming growth factor protein family. They are survival factors for peripheral and central neurons, for oligodendrocytes and can promote morphogenesis of kidney in vitro.
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Keywords

Neurotrophic polypeptides. GDNF protein family. Survival factors for nervous system.

About this article
Title

Glial line-derived neurotrophic factor (GDNF): Biological activities

Journal

Folia Morphologica

Issue

Vol 58, No 3 (1999)

Pages

155-159

Published online

2000-05-15

Bibliographic record

Folia Morphol 1999;58(3):155-159.

Keywords

Neurotrophic polypeptides. GDNF protein family. Survival factors for nervous system.

Authors

Woźniak W

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