Tangential migration of neurons during the development of the cerebral neocortex

Abstract

Two.forms of neuronal migration have been described in the developing brain: radial migration in which young neurons climb on the shafts of radial glial cells, and tangential migration, in which cells move parallel to the surface of the ventricles and perpendicular to radial grlia. The tangential migration occurs in multiple regions of the central nervous system. The relative prevalence of tangential versus radial migration has been estimated to be between 1O% to 70%, depending perhaps on the regions of the central nervous system, the time of migration, and animal species studied