open access

Vol 59, No 4 (2000)
ORIGINAL ARTICLES
Published online: 2000-08-02
Submitted: 2012-02-06
Get Citation

Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors

Sawsan Tabbaa, Christopher Goulah, Robert K Tran, Agnieszka Lis, Robert Korody, Brian Stachowski, Judith M Horowitz, German Torres, Ewa K Stachowiak, David C Bloom, Michał K Stachowiak
Folia Morphol 2000;59(4):221-232.

open access

Vol 59, No 4 (2000)
ORIGINAL ARTICLES
Published online: 2000-08-02
Submitted: 2012-02-06

Abstract

Manipulation of gene expression in developing or in mature central nervous systems (CNS) holds a promise for the resolution of many compelling neurobiological questions, including the feasibility of gene therapy to treat diseases of the brain. In this context, a number of viral vectors has been used in recent years to introduce and express genes into the CNS. This article discusses a gene transfer system based on the Herpes Simplex Virus-1 (HSV-1). We describe here the use of non-replicating, non-toxic HSV-1 vector, 8117/43, in a series of studies carried in our joint program. This vector proves further the utility of HSV-1 as a delivery vehicle to a number of distinct sites within the CNS.

Abstract

Manipulation of gene expression in developing or in mature central nervous systems (CNS) holds a promise for the resolution of many compelling neurobiological questions, including the feasibility of gene therapy to treat diseases of the brain. In this context, a number of viral vectors has been used in recent years to introduce and express genes into the CNS. This article discusses a gene transfer system based on the Herpes Simplex Virus-1 (HSV-1). We describe here the use of non-replicating, non-toxic HSV-1 vector, 8117/43, in a series of studies carried in our joint program. This vector proves further the utility of HSV-1 as a delivery vehicle to a number of distinct sites within the CNS.
Get Citation

Keywords

Herpes Simplex Virus-1; substantia nigra; hippocampus; β-galactosidase; gene therapy

About this article
Title

Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors

Journal

Folia Morphologica

Issue

Vol 59, No 4 (2000)

Pages

221-232

Published online

2000-08-02

Bibliographic record

Folia Morphol 2000;59(4):221-232.

Keywords

Herpes Simplex Virus-1
substantia nigra
hippocampus
β-galactosidase
gene therapy

Authors

Sawsan Tabbaa
Christopher Goulah
Robert K Tran
Agnieszka Lis
Robert Korody
Brian Stachowski
Judith M Horowitz
German Torres
Ewa K Stachowiak
David C Bloom
Michał K Stachowiak

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By  "Via Medica sp. z o.o." sp.k., Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl