Vol 59, No 4 (2000)
Original article
Published online: 2000-08-02
Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors
Folia Morphol 2000;59(4):221-232.
Abstract
Manipulation of gene expression in developing or in mature central nervous systems (CNS) holds a promise for the resolution of many compelling neurobiological questions, including the feasibility of gene therapy to treat diseases of the brain. In this context, a number of viral vectors has been used in recent years to introduce and express genes into the CNS. This article discusses a gene transfer system based on the Herpes Simplex Virus-1 (HSV-1). We describe here the use of non-replicating, non-toxic HSV-1 vector, 8117/43, in a series of studies carried in our joint program. This vector proves further the utility of HSV-1 as a delivery vehicle to a number of distinct sites within the CNS.
Keywords: Herpes Simplex Virus-1substantia nigrahippocampusβ-galactosidasegene therapy