open access

Vol 60, No 2 (2001)
ORIGINAL ARTICLES
Published online: 2001-02-14
Submitted: 2012-02-06
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A comparative study on oncostatin M secretion by transplantable melanoma cells with regard to their biological properties and progression

Krystyna Kozłowska, Małgorzata Zarzeczna, Mirosława Cichorek
Folia Morphol 2001;60(2):85-89.

open access

Vol 60, No 2 (2001)
ORIGINAL ARTICLES
Published online: 2001-02-14
Submitted: 2012-02-06

Abstract

The authors have studied oncostatin M secretory activity of cells of two lines of transplantable melanoma with different biological properties. The level of OSM in melanoma cells supernatant was determined by ELISA test and OSM bioactivity was measured by using biotest line sensitive to OSM cytostatic activity - A 375 melanoma cells. OSM presence was confirmed in cellular lysates by western blot. It has been demonstrated that a spontaneous alteration of the transplantable melanotic melanoma line into an amelanotic line connected with tumour progression was accompanied by an increase of OSM release.

Abstract

The authors have studied oncostatin M secretory activity of cells of two lines of transplantable melanoma with different biological properties. The level of OSM in melanoma cells supernatant was determined by ELISA test and OSM bioactivity was measured by using biotest line sensitive to OSM cytostatic activity - A 375 melanoma cells. OSM presence was confirmed in cellular lysates by western blot. It has been demonstrated that a spontaneous alteration of the transplantable melanotic melanoma line into an amelanotic line connected with tumour progression was accompanied by an increase of OSM release.
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Keywords

transplantable melanoma progression; OSM secretion

About this article
Title

A comparative study on oncostatin M secretion by transplantable melanoma cells with regard to their biological properties and progression

Journal

Folia Morphologica

Issue

Vol 60, No 2 (2001)

Pages

85-89

Published online

2001-02-14

Bibliographic record

Folia Morphol 2001;60(2):85-89.

Keywords

transplantable melanoma progression
OSM secretion

Authors

Krystyna Kozłowska
Małgorzata Zarzeczna
Mirosława Cichorek

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