Pecam-1 expression in patients with relapsing-remitting multiple sclerosis

Adam Niezgoda; Jacek Losy

Vol 61, No 3 (2002)

Original article

Submitted: 2012-02-06

Published online: 2002-05-23

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Pecam-1 expression in patients with relapsing-remitting multiple sclerosis

Adam Niezgoda, Jacek Losy

Folia Morphol 2002;61(3):143-145.

Vol 61, No 3 (2002)

ORIGINAL ARTICLES

Submitted: 2012-02-06

Published online: 2002-05-23

Abstract

PECAM-1 is an adhesion molecule - a member of the immunoglobulin superfamily - involved in the transendothelial migration of leukocytes. PECAM-1 is expressed on lymphocytes, monocytes and granulocytes. It is also found on endothelial cells and platelets. We present data showing that the cell-bound form of PECAM-1 expression on monocytes is increased in MS patients, compared to controls. We also show that PECAM-1 is significantly over-expressed on lymphocytes in patients with active MRI lesions, when compared to those without gadolinium-enhancing lesions. Our results suggest that the cell-bound form of PECAM-1 can be regarded as a marker of MS activity.