Vol 61, No 3 (2002)
Original article
Published online: 2002-05-23
Pecam-1 expression in patients with relapsing-remitting multiple sclerosis
Folia Morphol 2002;61(3):143-145.
Abstract
PECAM-1 is an adhesion molecule - a member of the immunoglobulin superfamily
- involved in the transendothelial migration of leukocytes. PECAM-1 is
expressed on lymphocytes, monocytes and granulocytes. It is also found on
endothelial cells and platelets. We present data showing that the cell-bound
form of PECAM-1 expression on monocytes is increased in MS patients, compared
to controls. We also show that PECAM-1 is significantly over-expressed on
lymphocytes in patients with active MRI lesions, when compared to those without
gadolinium-enhancing lesions. Our results suggest that the cell-bound form
of PECAM-1 can be regarded as a marker of MS activity.
Keywords: multiple sclerosisPECAM-1adhesion molecules