open access

Vol 61, No 3 (2002)
ORIGINAL ARTICLES
Published online: 2002-05-23
Submitted: 2012-02-06
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Estimation of macrophage IL-10 and NO secretion in the cytotoxicity against transplantable melanomas in relation to the progression of these tumours

Krystyna Kozłowska, Miroslawa Cichorek, Małgorzata Zarzeczna
Folia Morphol 2002;61(3):127-131.

open access

Vol 61, No 3 (2002)
ORIGINAL ARTICLES
Published online: 2002-05-23
Submitted: 2012-02-06

Abstract

The relationship between the secretion of interleukin 10 (IL-10) and nitric oxide (NO) by hamster peritoneal macrophages and their cytotoxic effects on the cells of those two melanoma lines was studied.
The nonuniform reaction of macrophages from hamsters bearing two transplantable melanoma lines has been observed. An increase in the cytotoxicity of macrophages from hamsters bearing the amelanotic melanoma line was accompanied by an inverse correlation between IL-10 and NO secretion. Such a relationship was not found in the case of macrophages from animals bearing the native-melanotic melanoma line. It is suggested that the phenotypical changes of melanomas connected with their progression modified the cytotoxic and secretory activity of the macrophages with regard to IL-10 and NO.

Abstract

The relationship between the secretion of interleukin 10 (IL-10) and nitric oxide (NO) by hamster peritoneal macrophages and their cytotoxic effects on the cells of those two melanoma lines was studied.
The nonuniform reaction of macrophages from hamsters bearing two transplantable melanoma lines has been observed. An increase in the cytotoxicity of macrophages from hamsters bearing the amelanotic melanoma line was accompanied by an inverse correlation between IL-10 and NO secretion. Such a relationship was not found in the case of macrophages from animals bearing the native-melanotic melanoma line. It is suggested that the phenotypical changes of melanomas connected with their progression modified the cytotoxic and secretory activity of the macrophages with regard to IL-10 and NO.
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Keywords

NO; interleukin 10; cytotoxicity macrophages; transplantable melanomas

About this article
Title

Estimation of macrophage IL-10 and NO secretion in the cytotoxicity against transplantable melanomas in relation to the progression of these tumours

Journal

Folia Morphologica

Issue

Vol 61, No 3 (2002)

Pages

127-131

Published online

2002-05-23

Bibliographic record

Folia Morphol 2002;61(3):127-131.

Keywords

NO
interleukin 10
cytotoxicity macrophages
transplantable melanomas

Authors

Krystyna Kozłowska
Miroslawa Cichorek
Małgorzata Zarzeczna

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