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Estimation of macrophage IL-10 and NO secretion in the cytotoxicity against transplantable melanomas in relation to the progression of these tumours
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Abstract
The nonuniform reaction of macrophages from hamsters bearing two transplantable melanoma lines has been observed. An increase in the cytotoxicity of macrophages from hamsters bearing the amelanotic melanoma line was accompanied by an inverse correlation between IL-10 and NO secretion. Such a relationship was not found in the case of macrophages from animals bearing the native-melanotic melanoma line. It is suggested that the phenotypical changes of melanomas connected with their progression modified the cytotoxic and secretory activity of the macrophages with regard to IL-10 and NO.
Abstract
The nonuniform reaction of macrophages from hamsters bearing two transplantable melanoma lines has been observed. An increase in the cytotoxicity of macrophages from hamsters bearing the amelanotic melanoma line was accompanied by an inverse correlation between IL-10 and NO secretion. Such a relationship was not found in the case of macrophages from animals bearing the native-melanotic melanoma line. It is suggested that the phenotypical changes of melanomas connected with their progression modified the cytotoxic and secretory activity of the macrophages with regard to IL-10 and NO.
Keywords
NO; interleukin 10; cytotoxicity macrophages; transplantable melanomas
About this articleTitle
Estimation of macrophage IL-10 and NO secretion in the cytotoxicity against transplantable melanomas in relation to the progression of these tumours
Journal
Issue
Article type
Original article
Pages
127-131
Published online
2002-05-23
Page views
428
Article views/downloads
1084
Bibliographic record
Folia Morphol 2002;61(3):127-131.
Keywords
NO
interleukin 10
cytotoxicity macrophages
transplantable melanomas
Authors
Krystyna Kozłowska
Miroslawa Cichorek
Małgorzata Zarzeczna
