open access

Vol 62, No 3 (2003)
Short Communications
Published online: 2003-06-09
Submitted: 2012-02-06
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A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

Elżbieta Czykier, Janusz Dzięcioł, Anna Zalewska, Krzysztof Zwierz
Folia Morphol 2003;62(3):305-307.

open access

Vol 62, No 3 (2003)
Short Communications
Published online: 2003-06-09
Submitted: 2012-02-06

Abstract

The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm3 affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm3, while the group II animals were given 50 mg Cd/dm3. The highest concentration of cadmium was observed in group II, with a concomitant increase in the number of PCNA-positive cells. In group I, cadmium concentration was significantly less compared to group II, and there were fewer PCNA-positive cells. The reaction for Ki-67 in both experimental groups was negative.

Abstract

The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm3 affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm3, while the group II animals were given 50 mg Cd/dm3. The highest concentration of cadmium was observed in group II, with a concomitant increase in the number of PCNA-positive cells. In group I, cadmium concentration was significantly less compared to group II, and there were fewer PCNA-positive cells. The reaction for Ki-67 in both experimental groups was negative.
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Keywords

rat; submandibular gland; cadmium intoxication

About this article
Title

A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

Journal

Folia Morphologica

Issue

Vol 62, No 3 (2003)

Pages

305-307

Published online

2003-06-09

Bibliographic record

Folia Morphol 2003;62(3):305-307.

Keywords

rat
submandibular gland
cadmium intoxication

Authors

Elżbieta Czykier
Janusz Dzięcioł
Anna Zalewska
Krzysztof Zwierz

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