A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

Elżbieta Czykier; Janusz Dzięcioł; Anna Zalewska; Krzysztof Zwierz

Vol 62, No 3 (2003)

Short communication

Submitted: 2012-02-06

Published online: 2003-06-09

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A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

Elżbieta Czykier, Janusz Dzięcioł, Anna Zalewska, Krzysztof Zwierz

Folia Morphol 2003;62(3):305-307.

Vol 62, No 3 (2003)

SHORT COMMUNICATIONS

Submitted: 2012-02-06

Published online: 2003-06-09

Abstract

The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm³ affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm³, while the group II animals were given 50 mg Cd/dm³. The highest concentration of cadmium was observed in group II, with a concomitant increase in the number of PCNA-positive cells. In group I, cadmium concentration was significantly less compared to group II, and there were fewer PCNA-positive cells. The reaction for Ki-67 in both experimental groups was negative.