Vol 62, No 4 (2003)
Short communication
Submitted: 2012-02-06
Published online: 2003-09-05
The expression of selected neuroendocrine markers and of anti-neoplastic cytokines (IL-2 and IL-12) in lung cancers
Aldona Kasprzak, Mariola Przewoźna, Joanna Surdyk-Zasada, Maciej Zabel
Folia Morphol 2003;62(4):497-499.
Vol 62, No 4 (2003)
SHORT COMMUNICATIONS
Submitted: 2012-02-06
Published online: 2003-09-05
Abstract
We have continued our studies by detecting three markers of neuroendocrine
tumours of the lungs, including chromogranin A, NSE and synaptophysin, to
confirm the neuroendocrine origin of lung tumours and by examining the content
of two anti-neoplastic cytokines, IL-2 and IL-12 in the tumours. The studies
were performed on paraffin sections of lung carcinoids (n = 13) and small cell
lung carcinomas (SCLC) (n = 15). Pronounced expression of all 3 markers of
neuroendocrine tumours was detected in most of the pulmonary carcinoids and
in 5/15 of SCLC. Co-expression of the two cytokines (IL-2 and IL-12) in tumour
cells was detected in 12/13 patients with lung carcinoid and expression of at
least one cytokine in 12/15 patients with SCLC. Significantly lower numbers of
cells immunoreactive to both cytokines were detected in SCLC as compared to
lung carcinoids. The studies have confirmed the literature data on the lowered
secretion of IL-2 in SCLC and extend the data by supplying information on the
expression of IL-12. The lowered expression of the two cytokines at the time of
diagnosis may represent a prognostic factor for survival in SCLC.
Abstract
We have continued our studies by detecting three markers of neuroendocrine
tumours of the lungs, including chromogranin A, NSE and synaptophysin, to
confirm the neuroendocrine origin of lung tumours and by examining the content
of two anti-neoplastic cytokines, IL-2 and IL-12 in the tumours. The studies
were performed on paraffin sections of lung carcinoids (n = 13) and small cell
lung carcinomas (SCLC) (n = 15). Pronounced expression of all 3 markers of
neuroendocrine tumours was detected in most of the pulmonary carcinoids and
in 5/15 of SCLC. Co-expression of the two cytokines (IL-2 and IL-12) in tumour
cells was detected in 12/13 patients with lung carcinoid and expression of at
least one cytokine in 12/15 patients with SCLC. Significantly lower numbers of
cells immunoreactive to both cytokines were detected in SCLC as compared to
lung carcinoids. The studies have confirmed the literature data on the lowered
secretion of IL-2 in SCLC and extend the data by supplying information on the
expression of IL-12. The lowered expression of the two cytokines at the time of
diagnosis may represent a prognostic factor for survival in SCLC.
Keywords
smallcell lung carcinoma; lung carcinoid; IL-2 and IL-12 expression; immunocytochemistry
Title
The expression of selected neuroendocrine markers and of anti-neoplastic cytokines (IL-2 and IL-12) in lung cancers
Journal
Folia Morphologica
Issue
Vol 62, No 4 (2003)
Article type
Short communication
Pages
497-499
Published online
2003-09-05
Page views
1065
Article views/downloads
1124
Bibliographic record
Folia Morphol 2003;62(4):497-499.
Keywords
smallcell lung carcinoma
lung carcinoid
IL-2 and IL-12 expression
immunocytochemistry
Authors
Aldona Kasprzak
Mariola Przewoźna
Joanna Surdyk-Zasada
Maciej Zabel