open access

Vol 62, No 4 (2003)
SHORT COMMUNICATIONS
Published online: 2003-09-05
Submitted: 2012-02-06
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The expression of selected neuroendocrine markers and of anti-neoplastic cytokines (IL-2 and IL-12) in lung cancers

Aldona Kasprzak, Mariola Przewoźna, Joanna Surdyk-Zasada, Maciej Zabel
Folia Morphol 2003;62(4):497-499.

open access

Vol 62, No 4 (2003)
SHORT COMMUNICATIONS
Published online: 2003-09-05
Submitted: 2012-02-06

Abstract

We have continued our studies by detecting three markers of neuroendocrine tumours of the lungs, including chromogranin A, NSE and synaptophysin, to confirm the neuroendocrine origin of lung tumours and by examining the content of two anti-neoplastic cytokines, IL-2 and IL-12 in the tumours. The studies were performed on paraffin sections of lung carcinoids (n = 13) and small cell lung carcinomas (SCLC) (n = 15). Pronounced expression of all 3 markers of neuroendocrine tumours was detected in most of the pulmonary carcinoids and in 5/15 of SCLC. Co-expression of the two cytokines (IL-2 and IL-12) in tumour cells was detected in 12/13 patients with lung carcinoid and expression of at least one cytokine in 12/15 patients with SCLC. Significantly lower numbers of cells immunoreactive to both cytokines were detected in SCLC as compared to lung carcinoids. The studies have confirmed the literature data on the lowered secretion of IL-2 in SCLC and extend the data by supplying information on the expression of IL-12. The lowered expression of the two cytokines at the time of diagnosis may represent a prognostic factor for survival in SCLC.

Abstract

We have continued our studies by detecting three markers of neuroendocrine tumours of the lungs, including chromogranin A, NSE and synaptophysin, to confirm the neuroendocrine origin of lung tumours and by examining the content of two anti-neoplastic cytokines, IL-2 and IL-12 in the tumours. The studies were performed on paraffin sections of lung carcinoids (n = 13) and small cell lung carcinomas (SCLC) (n = 15). Pronounced expression of all 3 markers of neuroendocrine tumours was detected in most of the pulmonary carcinoids and in 5/15 of SCLC. Co-expression of the two cytokines (IL-2 and IL-12) in tumour cells was detected in 12/13 patients with lung carcinoid and expression of at least one cytokine in 12/15 patients with SCLC. Significantly lower numbers of cells immunoreactive to both cytokines were detected in SCLC as compared to lung carcinoids. The studies have confirmed the literature data on the lowered secretion of IL-2 in SCLC and extend the data by supplying information on the expression of IL-12. The lowered expression of the two cytokines at the time of diagnosis may represent a prognostic factor for survival in SCLC.
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Keywords

smallcell lung carcinoma; lung carcinoid; IL-2 and IL-12 expression; immunocytochemistry

About this article
Title

The expression of selected neuroendocrine markers and of anti-neoplastic cytokines (IL-2 and IL-12) in lung cancers

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Pages

497-499

Published online

2003-09-05

Bibliographic record

Folia Morphol 2003;62(4):497-499.

Keywords

smallcell lung carcinoma
lung carcinoid
IL-2 and IL-12 expression
immunocytochemistry

Authors

Aldona Kasprzak
Mariola Przewoźna
Joanna Surdyk-Zasada
Maciej Zabel

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