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The expression of metallothionein (MT) and proliferation intensity in ovarian cancers treated with cisplatin and paclitaxel
open access
Abstract
The experiments were performed on samples originating from 10 patients operated on due to ovarian cancer. The material originated from the first operations or second-look operations. All the patients were treated with cisplatin and paclitaxel. Immunocytochemical reactions using antibodies to MT, Ki67 and PCNA were performed in paraffin sections originating from the cases studied. Statistical analysis was performed using Statistica software. The studies demonstrated no relation between expression of MT on the one hand and intensity of proliferation before or after chemotherapy on the other hand (gamma correlation, p > 0.05). The results indicate that expression of MT is not related to resistance to treatment using cisplatin and paclitaxel.
Abstract
The experiments were performed on samples originating from 10 patients operated on due to ovarian cancer. The material originated from the first operations or second-look operations. All the patients were treated with cisplatin and paclitaxel. Immunocytochemical reactions using antibodies to MT, Ki67 and PCNA were performed in paraffin sections originating from the cases studied. Statistical analysis was performed using Statistica software. The studies demonstrated no relation between expression of MT on the one hand and intensity of proliferation before or after chemotherapy on the other hand (gamma correlation, p > 0.05). The results indicate that expression of MT is not related to resistance to treatment using cisplatin and paclitaxel.
Keywords
ovarian cancer; metallothionein; proliferation; cisplatin; paclitaxel
Title
The expression of metallothionein (MT) and proliferation intensity in ovarian cancers treated with cisplatin and paclitaxel
Journal
Issue
Article type
Short communication
Pages
493-495
Published online
2003-09-05
Page views
438
Article views/downloads
1119
Bibliographic record
Folia Morphol 2003;62(4):493-495.
Keywords
ovarian cancer
metallothionein
proliferation
cisplatin
paclitaxel
Authors
Paweł Surowiak
Irina Kaplenko
Marek Spaczyński
Maciej Zabel