Vol 62, No 4 (2003)
Short communication
Published online: 2003-09-05
Tissue expression of cytokines (IL-1α, IL-2, IL-6, IL-12, TNF-α) in B-cell lymphomas in children
Folia Morphol 2003;62(4):483-484.
Abstract
In most malignant tumours disturbed production of cytokines and of their receptors
can be noted. The main immune system cells engaged in tumour regression
with the involvement of cytokines include helper lymphocytes (Th1), cytotoxic
lymphocytes (Tc) and dendritic cells. It has been noted that cytokines are
also produced by the cells of a tumour. The present study aimed at immunocytochemical
localisation of cytokines (IL-1α, IL-2, IL-6, IL-12, TNF-α) in B-cell lymphomas
in children (n = 10). The studies were performed on surgical material
following formalin fixation and embedding in paraffin. The control material involved
human reactive lymph nodes (n = 5). IL-2, IL-6, IL-12 were detected in
4/10 examined cases. Expression of IL-1α was highly pronounced, as in the
control, and was detected in 6/9 examined patients. No TNF-α could be demonstrated
in tumours even if lymph node expression of the cytokine was demonstrated
in the control. The studies pointed to a decreased production of antitumour
cytokines in B-cell lymphomas in children, which might correspond to
the progression of the tumour.
Keywords: non-Hodgkin’s B-cell lymphomaschildrenIL-1αIL-2IL-6IL-12TNF-αimmunocytochemistry