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Vol 62, No 4 (2003)
Short communication
Submitted: 2012-02-06
Published online: 2003-09-05
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The influence of experimental Bacteroides fragilis infection on substance P and somatostatin-immunoreactive neural elements in the porcine ascending colon - a preliminary report

Sławomir Gonkowski, Barbara Kamińska, Agnieszka Bossowska, Maria Korzon, Piotr Landowski, Mariusz Majewski
Folia Morphol 2003;62(4):455-457.

open access

Vol 62, No 4 (2003)
SHORT COMMUNICATIONS
Submitted: 2012-02-06
Published online: 2003-09-05

Abstract

The present study was aimed at disclosing the influence of Bacteroides fragilis (one of the most important bacterial agents causing colitis in children) experimental infection on the expression of substance P (SP) and somatostatin (SOM) in neurons and nerve fibres within the porcine ascending colon. Distinct differences in the distribution pattern of neural elements immunoreactive to the substances studied were observed between the experimental (Inflam) and control (Contr) pigs. In general, the number of SP-IR neurons and nerve terminals increased, while the expression of SOM decreased after Bacteroides fragilis-induced colitis (BFIC). However, distinct differences in the intensity of these alterations were observed between particular compartments of the bowel segment studied. Thus, the present results suggest that SP- and SOM-immunoreactive (SOM-IR) elements of the enteric nervous system play a part in the control of colonic activity during BFIC.

Abstract

The present study was aimed at disclosing the influence of Bacteroides fragilis (one of the most important bacterial agents causing colitis in children) experimental infection on the expression of substance P (SP) and somatostatin (SOM) in neurons and nerve fibres within the porcine ascending colon. Distinct differences in the distribution pattern of neural elements immunoreactive to the substances studied were observed between the experimental (Inflam) and control (Contr) pigs. In general, the number of SP-IR neurons and nerve terminals increased, while the expression of SOM decreased after Bacteroides fragilis-induced colitis (BFIC). However, distinct differences in the intensity of these alterations were observed between particular compartments of the bowel segment studied. Thus, the present results suggest that SP- and SOM-immunoreactive (SOM-IR) elements of the enteric nervous system play a part in the control of colonic activity during BFIC.

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Keywords

Bacteroides fragilis infection; colitis; substance P; somatostatin; pig

About this article
Title

The influence of experimental Bacteroides fragilis infection on substance P and somatostatin-immunoreactive neural elements in the porcine ascending colon - a preliminary report

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Article type

Short communication

Pages

455-457

Published online

2003-09-05

Page views

647

Article views/downloads

1435

Bibliographic record

Folia Morphol 2003;62(4):455-457.

Keywords

Bacteroides fragilis infection
colitis
substance P
somatostatin
pig

Authors

Sławomir Gonkowski
Barbara Kamińska
Agnieszka Bossowska
Maria Korzon
Piotr Landowski
Mariusz Majewski

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