Vol 62, No 4 (2003)
Case report
Submitted: 2012-02-06
Published online: 2003-09-05
The expression of selected immunocytochemical diagnostic markers in the case of chondrosarcoma with a mesenchymal component
Wojciech Rzeszutko, Piotr Dzięgiel, Marta Rzeszutko, Andrzej Wojnar
Folia Morphol 2003;62(4):513-515.
Vol 62, No 4 (2003)
CASE REPORTS
Submitted: 2012-02-06
Published online: 2003-09-05
Abstract
The case of 52-year-old man is presented, who had suffered from pains in his
right brachial region and in whom, upon admission to the Lower Silesia Centre
of Oncology, a tumour of 20 cm in diameter and restricted mobility was disclosed
in the right brachial region and proximal 1/3 of his right arm. Radiograms
of his right humerus disclosed non-uniform restructuring of the osseous tissue,
dominated by osteosclerosis in the upper half of his right humerus, while in the
surrounding dift tissues of the proximal portion non-uniform shades were seen
of calcified appearance. The patient was qualified to surgical biopsy and histopathological
examination of the sample disclosed Chondrosarcoma G II. Following
amputation of the right upper extremity together with the scapula, the tumour
was subjected to histopathological and immunocytochemical examination
in the Department of Pathomorphology, Lower Silesia Centre of Oncology. In
numerous samples of the tumour dedifferentiated chondrosarcoma was diagnosed
with a dominating component of malignant fibrous histiocytoma (MFH),
which was confirmed by detecting a high expression of alpha-1-antichymotrypsin
(ACT) within the spindle-shaped cell component of the chondrosarcoma.
Spindle-shaped elements in dedifferentiated chondrosarcoma (DChSa) may represent
patterns of fibrosarcoma, osteosarcoma or the malignant fibrohistiocytoma
(MFH) type and they are present as if in the form of restricted fields with
no reciprocal infiltrates. Moreover, due to the worse prognosis in the case of the
MFH component in dedifferentiated chondrosarcoman as compared to that in
classical chondrosarcoma, common evaluation of the material was made by
a surgeon, radiologist and histopathologist, accompanied by a minimum panel
of immunocytochemical tests (ACT, Vimentyna, Desmina, S-100). This enabled
a final diagnosis for all tumour components to be established and prognosis to
be made regarding the further fate of the patient.
Abstract
The case of 52-year-old man is presented, who had suffered from pains in his
right brachial region and in whom, upon admission to the Lower Silesia Centre
of Oncology, a tumour of 20 cm in diameter and restricted mobility was disclosed
in the right brachial region and proximal 1/3 of his right arm. Radiograms
of his right humerus disclosed non-uniform restructuring of the osseous tissue,
dominated by osteosclerosis in the upper half of his right humerus, while in the
surrounding dift tissues of the proximal portion non-uniform shades were seen
of calcified appearance. The patient was qualified to surgical biopsy and histopathological
examination of the sample disclosed Chondrosarcoma G II. Following
amputation of the right upper extremity together with the scapula, the tumour
was subjected to histopathological and immunocytochemical examination
in the Department of Pathomorphology, Lower Silesia Centre of Oncology. In
numerous samples of the tumour dedifferentiated chondrosarcoma was diagnosed
with a dominating component of malignant fibrous histiocytoma (MFH),
which was confirmed by detecting a high expression of alpha-1-antichymotrypsin
(ACT) within the spindle-shaped cell component of the chondrosarcoma.
Spindle-shaped elements in dedifferentiated chondrosarcoma (DChSa) may represent
patterns of fibrosarcoma, osteosarcoma or the malignant fibrohistiocytoma
(MFH) type and they are present as if in the form of restricted fields with
no reciprocal infiltrates. Moreover, due to the worse prognosis in the case of the
MFH component in dedifferentiated chondrosarcoman as compared to that in
classical chondrosarcoma, common evaluation of the material was made by
a surgeon, radiologist and histopathologist, accompanied by a minimum panel
of immunocytochemical tests (ACT, Vimentyna, Desmina, S-100). This enabled
a final diagnosis for all tumour components to be established and prognosis to
be made regarding the further fate of the patient.
Keywords
dedifferentiated chondrosarcoma; dedifferentiated sarcomas
Title
The expression of selected immunocytochemical diagnostic markers in the case of chondrosarcoma with a mesenchymal component
Journal
Folia Morphologica
Issue
Vol 62, No 4 (2003)
Article type
Case report
Pages
513-515
Published online
2003-09-05
Page views
441
Article views/downloads
935
Bibliographic record
Folia Morphol 2003;62(4):513-515.
Keywords
dedifferentiated chondrosarcoma
dedifferentiated sarcomas
Authors
Wojciech Rzeszutko
Piotr Dzięgiel
Marta Rzeszutko
Andrzej Wojnar