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Vol 62, No 4 (2003)
Original article
Submitted: 2012-02-06
Published online: 2003-09-05
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The correlation of protein peroxidation with morphological changes in experimental oestradiol-induced carcinogenesis

Jarosław Kobiela, Jolanta Kubasik-Juraniec, Tomasz Stefaniak, Jacek Krajewski, Guido Bellezza, Emilio Bucciarelli, Paulina Kryger, Andrzej Lachinski, Zbigniew Gruca, Jan H. Spodnik, Michał Woźniak
Folia Morphol 2003;62(4):341-346.

open access

Vol 62, No 4 (2003)
ORIGINAL ARTICLES
Submitted: 2012-02-06
Published online: 2003-09-05

Abstract

Oestradiol-induced male Syrian hamster carcinogenesis is a well-known experimental model of human cancer of the breast, ovary and uterus. The pathomechanism postulated in this model is 4-hydroxylation of oestradiol and further free radical formation. The same process is suspected in human breast cancer. Dynamic changes in protein peroxidation were reported during the tumour induction. In this paper we try to correlate the protein peroxidation markers with the histopathological progression of the changes. The biochemical and histopathological evaluations were performed after 1, 3, 6 and 9 months of the hormone exposition. Significant protein peroxidation was observed as soon as after 1 month and increased further until the 6th month. After 9 months however, it was not significantly different from the control. The discrete histopathological changes after 1 month, progressed into tubular and interstitial hyperplasias after 3 and 6 months. After 9 months several dysplastic areas, sometimes with features of carcinoma in situ, were observed. The severe 9-month histopathological changes did not correlate with the protein peroxidation.

Abstract

Oestradiol-induced male Syrian hamster carcinogenesis is a well-known experimental model of human cancer of the breast, ovary and uterus. The pathomechanism postulated in this model is 4-hydroxylation of oestradiol and further free radical formation. The same process is suspected in human breast cancer. Dynamic changes in protein peroxidation were reported during the tumour induction. In this paper we try to correlate the protein peroxidation markers with the histopathological progression of the changes. The biochemical and histopathological evaluations were performed after 1, 3, 6 and 9 months of the hormone exposition. Significant protein peroxidation was observed as soon as after 1 month and increased further until the 6th month. After 9 months however, it was not significantly different from the control. The discrete histopathological changes after 1 month, progressed into tubular and interstitial hyperplasias after 3 and 6 months. After 9 months several dysplastic areas, sometimes with features of carcinoma in situ, were observed. The severe 9-month histopathological changes did not correlate with the protein peroxidation.

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Keywords

oxidative stress; protein carbonyl groups; renal carcinogenesis; estrogen-induced carcinogenesis; morphology

About this article
Title

The correlation of protein peroxidation with morphological changes in experimental oestradiol-induced carcinogenesis

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Article type

Original article

Pages

341-346

Published online

2003-09-05

Page views

633

Article views/downloads

867

Bibliographic record

Folia Morphol 2003;62(4):341-346.

Keywords

oxidative stress
protein carbonyl groups
renal carcinogenesis
estrogen-induced carcinogenesis
morphology

Authors

Jarosław Kobiela
Jolanta Kubasik-Juraniec
Tomasz Stefaniak
Jacek Krajewski
Guido Bellezza
Emilio Bucciarelli
Paulina Kryger
Andrzej Lachinski
Zbigniew Gruca
Jan H. Spodnik
Michał Woźniak

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