open access

Vol 62, No 4 (2003)
ORIGINAL ARTICLES
Published online: 2003-09-05
Submitted: 2012-02-06
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Preliminary immunohistochemical investigations of thyroid C cells in an experimental model of hyperthyroidism

Jacek Dadan, Robert Ł. Zbucki, Bogusław Sawicki, Izabela Bialuk, Agnieszka Zawadzka, Maria M. Winnicka, Zbigniew Puchalski
Folia Morphol 2003;62(4):319-321.

open access

Vol 62, No 4 (2003)
ORIGINAL ARTICLES
Published online: 2003-09-05
Submitted: 2012-02-06

Abstract

The role of the parafollicular (C) cells, the second most important cells in the thyroid gland, has not hitherto been clarified. They are considered to be disperse neuroendocrine cells of the APUD system and synthesise and release many of the regulatory peptides. Few publications are concerned with the evaluation of the structure and function of C cells in the thyroid gland or the probable relationship between these cells and the follicular cells in physiological and pathological conditions. For this reason immunohistochemical investigations were carried out into the activity of the C cells in rats in an experimental model of hyperthyroidism caused by chronic thyroxine influence. This C-cell activity was then evaluated. Differences in the quantity, distribution and calcitonin immunoreactivity of C cells were observed in hyperthyroid rats in comparison to the control group, together with a significant diminution of plasma TSH and calcitonin levels. Our preliminary study may indicate a functional interaction between follicular and parafollicular cells in the thyroid gland.

Abstract

The role of the parafollicular (C) cells, the second most important cells in the thyroid gland, has not hitherto been clarified. They are considered to be disperse neuroendocrine cells of the APUD system and synthesise and release many of the regulatory peptides. Few publications are concerned with the evaluation of the structure and function of C cells in the thyroid gland or the probable relationship between these cells and the follicular cells in physiological and pathological conditions. For this reason immunohistochemical investigations were carried out into the activity of the C cells in rats in an experimental model of hyperthyroidism caused by chronic thyroxine influence. This C-cell activity was then evaluated. Differences in the quantity, distribution and calcitonin immunoreactivity of C cells were observed in hyperthyroid rats in comparison to the control group, together with a significant diminution of plasma TSH and calcitonin levels. Our preliminary study may indicate a functional interaction between follicular and parafollicular cells in the thyroid gland.
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Keywords

C cells; hyperthyroidism; calcitonin immunoreactivity

About this article
Title

Preliminary immunohistochemical investigations of thyroid C cells in an experimental model of hyperthyroidism

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Pages

319-321

Published online

2003-09-05

Bibliographic record

Folia Morphol 2003;62(4):319-321.

Keywords

C cells
hyperthyroidism
calcitonin immunoreactivity

Authors

Jacek Dadan
Robert Ł. Zbucki
Bogusław Sawicki
Izabela Bialuk
Agnieszka Zawadzka
Maria M. Winnicka
Zbigniew Puchalski

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