open access

Vol 63, No 2 (2004)
SHORT COMMUNICATIONS
Published online: 2004-03-12
Submitted: 2012-02-06
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Apoptotic changes in the myocardium in the course of experimentally-induced pleurisy

Całkosiński I, Cegielski M, Dzięgiel P, Skalik R, Majda J
Folia Morphol 2004;63(2):225-228.

open access

Vol 63, No 2 (2004)
SHORT COMMUNICATIONS
Published online: 2004-03-12
Submitted: 2012-02-06

Abstract

The secreted proinflammatory interleukins IL-1, IL-6 and TNF in the course of experimentally-induced pleurisy can be the cause of pathological changes in the ultrastructure of cardiac muscle and of apoptosis. The pleurisy was induced in rats by means of carrageenin. The scraps of cardiac muscle obtained during the inflammatory reaction in the pleura were analysed by means of an electron microscope. The scraps were also stained with the TUNEL method in order to find the apoptotic foci. It was proved by the experiment that the inflammatory process affected mitochondria in the cardiomyocytes, enhanced collagen fibre synthesis and contributed to the formation of apoptotic foci in the cardiac muscle.

Abstract

The secreted proinflammatory interleukins IL-1, IL-6 and TNF in the course of experimentally-induced pleurisy can be the cause of pathological changes in the ultrastructure of cardiac muscle and of apoptosis. The pleurisy was induced in rats by means of carrageenin. The scraps of cardiac muscle obtained during the inflammatory reaction in the pleura were analysed by means of an electron microscope. The scraps were also stained with the TUNEL method in order to find the apoptotic foci. It was proved by the experiment that the inflammatory process affected mitochondria in the cardiomyocytes, enhanced collagen fibre synthesis and contributed to the formation of apoptotic foci in the cardiac muscle.
Get Citation

Keywords

pleurisy; ultrastructure of cardiac muscle; apoptosis

About this article
Title

Apoptotic changes in the myocardium in the course of experimentally-induced pleurisy

Journal

Folia Morphologica

Issue

Vol 63, No 2 (2004)

Pages

225-228

Published online

2004-03-12

Bibliographic record

Folia Morphol 2004;63(2):225-228.

Keywords

pleurisy
ultrastructure of cardiac muscle
apoptosis

Authors

Całkosiński I
Cegielski M
Dzięgiel P
Skalik R
Majda J

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