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Morphological alterations in the seminiferous tubules of adult Wistar rats: the effects of prenatal ethanol exposure
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Abstract
The results demonstrated that prenatal ethanol exposure induced persistent growth retardation and a 66% reduction in testicular weight and severely altered the morphology of the seminiferous tubules of adult male rats, causing a reduction in the cross-sectional area of the tubules by 18%, germinal epithelium thickness by 21% (p < 0.001) and an inhibition of spermatogenesis. The study showed the absence of reticulin fibres in the peritubular tissue of seminiferous tubules of prenatal ethanol-exposed adult male rats. The results imply that damage following prenatal ethanol exposure occurs irreversibly in utero and persists into adulthood in the exposed animals, which may have implications for male fertility.
Abstract
The results demonstrated that prenatal ethanol exposure induced persistent growth retardation and a 66% reduction in testicular weight and severely altered the morphology of the seminiferous tubules of adult male rats, causing a reduction in the cross-sectional area of the tubules by 18%, germinal epithelium thickness by 21% (p < 0.001) and an inhibition of spermatogenesis. The study showed the absence of reticulin fibres in the peritubular tissue of seminiferous tubules of prenatal ethanol-exposed adult male rats. The results imply that damage following prenatal ethanol exposure occurs irreversibly in utero and persists into adulthood in the exposed animals, which may have implications for male fertility.
Keywords
germinal epithelium; reticulin; foetal alcohol syndrome; ethanol; male fertility; testes
Title
Morphological alterations in the seminiferous tubules of adult Wistar rats: the effects of prenatal ethanol exposure
Journal
Issue
Article type
Original article
Pages
195-202
Published online
2004-03-12
Page views
476
Article views/downloads
1849
Bibliographic record
Folia Morphol 2004;63(2):195-202.
Keywords
germinal epithelium
reticulin
foetal alcohol syndrome
ethanol
male fertility
testes
Authors
Fakoya FA
Caxton-Martins EA