Vol 63, No 4 (2004)
Original article
Submitted: 2012-02-06
Published online: 2004-09-16
Acute ischaemic stroke increases the erytrocyte sedimentation rate, which correlates with early brain damage
Jarosław Zaremba, Piotr Skrobański, Jacek Losy
Folia Morphol 2004;63(4):373-376.
Vol 63, No 4 (2004)
ORIGINAL ARTICLES
Submitted: 2012-02-06
Published online: 2004-09-16
Abstract
The acute phase response follows tissue injury and contributes to its exacerbation
with pro-inflammatory and pro-thrombotic mechanisms. Acute phase proteins
promote erythrocyte aggregation and falling, with the result that the erythrocyte
sedimentation rate (ESR) is a measure of the acute phase response.
As the acute phase response accompanies ischaemic brain damage, we studied
ESR values in patients within the first 24 hours of ischaemic stroke and evaluated
whether these values may be related to the volume of anatomically relevant
single hemispheric brain computed tomography (CT) areas observed at the same
period, indicating early stroke-related cerebral changes.
We observed an increase in ESR in stroke patients and a positive correlation
between the ESR values and the volume of early brain CT hypodense areas.
The results suggest that elevation in ESR values is observed soon after a stroke
and may reflect the relationship between the degree of acute phase response in
the early phase of ischaemic stroke and the extent of local brain damage.
Abstract
The acute phase response follows tissue injury and contributes to its exacerbation
with pro-inflammatory and pro-thrombotic mechanisms. Acute phase proteins
promote erythrocyte aggregation and falling, with the result that the erythrocyte
sedimentation rate (ESR) is a measure of the acute phase response.
As the acute phase response accompanies ischaemic brain damage, we studied
ESR values in patients within the first 24 hours of ischaemic stroke and evaluated
whether these values may be related to the volume of anatomically relevant
single hemispheric brain computed tomography (CT) areas observed at the same
period, indicating early stroke-related cerebral changes.
We observed an increase in ESR in stroke patients and a positive correlation
between the ESR values and the volume of early brain CT hypodense areas.
The results suggest that elevation in ESR values is observed soon after a stroke
and may reflect the relationship between the degree of acute phase response in
the early phase of ischaemic stroke and the extent of local brain damage.
Keywords
stroke; acute phase response; erythrocyte sedimentation rate
Title
Acute ischaemic stroke increases the erytrocyte sedimentation rate, which correlates with early brain damage
Journal
Folia Morphologica
Issue
Vol 63, No 4 (2004)
Article type
Original article
Pages
373-376
Published online
2004-09-16
Page views
510
Article views/downloads
2765
Bibliographic record
Folia Morphol 2004;63(4):373-376.
Keywords
stroke
acute phase response
erythrocyte sedimentation rate
Authors
Jarosław Zaremba
Piotr Skrobański
Jacek Losy