Histological studies of selected organs of mice experimentally infected with Acanthamoeba spp.

Abstract

Histological studies of the brain, lungs, liver, kidneys, heart, and the spleen were carried out in mice previously infected with 6 pathogenic strains of free-living amoebae of the genus Acanthamoeba. The potential virulence of the strains studied was determined on the basis of re-isolation of the amoebae from the organs of the inoculated animals and by the extent of the histopathological changes inflicted. The most virulent was strain AD16, affecting all organs of the inoculated mice, while the least virulent was strain AD148 re-isolated from the brain of a single mouse. The extent of the changes in the brain depended upon the amoebae strain, while in the remaining organs it also depended upon the duration of the infection.