The manufacture of synthetic non-sintered and degradable bone grafting substitutes

Abstract

A new synthetic bone grafting substitute (NanoBone®, ARTOSS GmbH, Germany) is presented. This is produced by a new technique, the sol-gel-method. This bone grafting substitute consists of nanocrystalline hydroxyapatite (HA) and nanostructured silica (SiO₂). By achieving a highly porous structure good osteoconductivity can be seen. In addition, the material will be completely biodegraded and new own bone is formed. It has been demonstrated that NanoBone® is biodegraded by osteoclasts in a manner comparable to the natural bone remodelling process.