open access

Vol 65, No 4 (2006)
REVIEW ARTICLES
Published online: 2006-09-18
Submitted: 2012-02-06
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The pathophysiology of intracerebral haemorrhage

Karwacki Z, Kowiański P, Witkowska M, Karwacka M, Dziewiątkowski J, Moryś J
Folia Morphol 2006;65(4):295-300.

open access

Vol 65, No 4 (2006)
REVIEW ARTICLES
Published online: 2006-09-18
Submitted: 2012-02-06

Abstract

Spontaneous intracerebral haemorrhage carries a high mortality rate and treatment of the disease raises more questions then answers. Mass effect, ischaemia and toxicity of blood components are responsible for brain tissue damage. Initially occurring disturbances of cerebral blood flow have a temporary character and do not play a key role in the pathology of intracerebral haematoma. Oedema formatting in the 24–48 hours after intracerebral bleeding is the result of multidirectional processes. The pathological mechanism that underlines it is the function of activation of systemic complement and cascade of coagulation. In the light of these findings, further clinical and experimental investigations should be focused on these factors.

Abstract

Spontaneous intracerebral haemorrhage carries a high mortality rate and treatment of the disease raises more questions then answers. Mass effect, ischaemia and toxicity of blood components are responsible for brain tissue damage. Initially occurring disturbances of cerebral blood flow have a temporary character and do not play a key role in the pathology of intracerebral haematoma. Oedema formatting in the 24–48 hours after intracerebral bleeding is the result of multidirectional processes. The pathological mechanism that underlines it is the function of activation of systemic complement and cascade of coagulation. In the light of these findings, further clinical and experimental investigations should be focused on these factors.
Get Citation

Keywords

intracerebral haemorrhage; oedema; systemic complement; inflammation; cytokines

About this article
Title

The pathophysiology of intracerebral haemorrhage

Journal

Folia Morphologica

Issue

Vol 65, No 4 (2006)

Pages

295-300

Published online

2006-09-18

Bibliographic record

Folia Morphol 2006;65(4):295-300.

Keywords

intracerebral haemorrhage
oedema
systemic complement
inflammation
cytokines

Authors

Karwacki Z
Kowiański P
Witkowska M
Karwacka M
Dziewiątkowski J
Moryś J

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